Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity
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DOI: 10.1007/s00213-018-4874-z
Abstract: RationaleAberrant glutamatergic, dopaminergic, and GABAergic neurotransmission has been implicated in schizophrenia. Cariprazine reverses the behavioral effects observed in the rat phencyclidine (PCP)-induced model of schizophrenia; however, little is known about its in vivo neurochemistry.ObjectivesThe study… read more here.
Keywords: cariprazine aripiprazole; serotonin; locomotor activity; extracellular levels ... See more keywords