Functional Analysis of Conserved Transmembrane Charged Residues and a Yeast Specific Extracellular Loop of the Plasma Membrane Na+/H+ Antiporter of Schizosaccharomyces pombe
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DOI: 10.1038/s41598-019-42658-0
Abstract: The Na+/H+ exchanger of the plasma membrane of S. pombe (SpNHE1) removes excess intracellular sodium in exchange for an extracellular proton. We examined the functional role of acidic amino acids of a yeast specific periplasmic… read more here.
Keywords: extracellular loop; yeast specific; spnhe1; plasma membrane ... See more keywords
The thematic role of extracellular loop of VraG in activation of the membrane sensor GraS in a cystic fibrosis MRSA strain differs in nuance from the CA-MRSA strain JE2
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DOI: 10.1371/journal.pone.0270393
Abstract: Patients with cystic fibrosis (CF) often suffer recurrent bronchial bacterial infections that lead to deterioration of lung function over time. The infections in CF patients are often due to S. aureus and P. aeruginosa that… read more here.
Keywords: strain je2; extracellular loop; strain; membrane ... See more keywords
A Novel Antibody Targeting the Second Extracellular Loop of the Serotonin 5-HT2A Receptor Inhibits Platelet Function
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DOI: 10.3390/ijms23158794
Abstract: Serotonin (5-hydroxytriptamine or 5-HT) is known to be a weak platelet agonist, and is involved in thrombus formation. While 5-HT cannot induce platelet aggregation on its own, when secreted from the alpha granules, it binds… read more here.
Keywords: extracellular loop; platelet; platelet function; receptor ... See more keywords
The Third Extracellular Loop of Mammalian Odorant Receptors Is Involved in Ligand Binding
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DOI: 10.3390/ijms232012501
Abstract: Mammals recognize chemicals in the air via G protein-coupled odorant receptors (ORs). In addition to their orthosteric binding site, other segments of these receptors modulate ligand recognition. Focusing on human hOR1A1, which is considered prototypical… read more here.
Keywords: mammalian odorant; third extracellular; odorant receptors; extracellular loop ... See more keywords
Recombinant Expression of ABCC2 Variants Confirms the Importance of Mutations in Extracellular Loop 4 for Cry1F Resistance in Fall Armyworm
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DOI: 10.3390/toxins14020157
Abstract: Fall armyworm (FAW), Spodoptera frugiperda, is a highly destructive and invasive global noctuid pest. Its control is based on insecticide applications and Bacillus thuringiensis (Bt) insecticidal Cry toxins expressed in transgenic crops, such as Cry1F… read more here.
Keywords: fall armyworm; extracellular loop; cry1f; resistance ... See more keywords