Environmental neurotoxicant manganese regulates exosome‐mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to &agr;‐synuclein misfolding in metal neurotoxicity
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2017.04.007
Abstract: Graphical abstract Figure. No caption available. HighlightsExposure to an environmental neurotoxin, Mn, can actively modulate exosome RNA cargo.Mn induces Rab27a to increase extracellular RNA via exosomes.Mn treatment alters exosomal small RNA profiling.Mn upregulates several miRNAs… read more here.
Keywords: agr; extracellular mirnas; parkinson disease; agr synuclein ... See more keywords
Improving the Diagnostic Potential of Extracellular miRNAs Coupled to Multiomics Data by Exploiting the Power of Artificial Intelligence
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.888414
Abstract: In recent years, the clinical use of extracellular miRNAs as potential biomarkers of disease has increasingly emerged as a new and powerful tool. Serum, urine, saliva and stool contain miRNAs that can exert regulatory effects… read more here.
Keywords: multiomics data; coupled multiomics; artificial intelligence; extracellular mirnas ... See more keywords