Therapeutic use of extracellular mitochondria in CNS injury and disease
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2019.113114
Abstract: In the central nervous system (CNS), neuronal functionality is highly dependent on mitochondrial integrity and activity. In the context of a damaged or diseased brain, mitochondrial dysfunction leads to reductions in ATP levels, thus impairing… read more here.
Keywords: use extracellular; therapeutic use; mitochondria cns; cns injury ... See more keywords
Quantitative cellular characterization of extracellular mitochondria uptake and delivery
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-64147-x
Abstract: Mitochondria are essential intracellular organelles responsible for energy production. Over the past two decades, unconventional intercellular mitochondrial transfer has been reported, but the nature of the transport intermediates, the efficiency of the process, and the… read more here.
Keywords: characterization extracellular; uptake delivery; quantitative cellular; cellular characterization ... See more keywords
Alternative mitochondrial quality control mediated by extracellular release
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DOI: 10.1080/15548627.2020.1848130
Abstract: ABSTRACT Mitochondrial quality control, which is crucial for maintaining cellular homeostasis, has been considered to be achieved exclusively through mitophagy. Here we report an alternative mitochondrial quality control pathway mediated by extracellular mitochondria release. By… read more here.
Keywords: protein; control; extracellular mitochondria; mitochondrial quality ... See more keywords
Extracellular Mitochondria and Vesicles.
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DOI: 10.1161/circresaha.119.315328
Abstract: Monocyte interaction with endothelial cells is regarded as a key step in acute and chronic vascular inflammatory diseases. For many years, unraveling cell secretome composition has been an area of extensive investigation to better understand… read more here.
Keywords: extracellular mitochondria; mitochondria vesicles; extracellular vesicles;
Extracellular Mitochondria Exacerbate Retinal Pigment Epithelium Degeneration in Diabetic Retinopathy.
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DOI: 10.2337/db24-0040
Abstract: Advances in fundus imaging are revealing disruptions in the neurovascular unit in diabetic retinopathy (DR). In the era of anti-VEGF treatment, a thorough characterization of neurodegeneration is imperative until DR patients are sufficiently cured. Here… read more here.
Keywords: degeneration; exacerbate retinal; mitochondria exacerbate; extracellular mitochondria ... See more keywords