Extracellular S100B inhibits A‐type voltage‐gated potassium currents and increases L‐type voltage‐gated calcium channel activity in dopaminergic neurons
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DOI: 10.1002/glia.24254
Abstract: Parkinson's disease (PD) is associated with an increase in secreted S100B within the midbrain and cerebrospinal fluid. In addition, S100B overexpression in mice accelerates the loss of substantia nigra pars compacta dopaminergic (DA) neurons, suggesting… read more here.
Keywords: type voltage; gated potassium; extracellular s100b; voltage gated ... See more keywords
Intracellular Protein S-Nitrosylation—A Cells Response to Extracellular S100B and RAGE Receptor
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DOI: 10.3390/biom12050613
Abstract: Human S100B is a small, multifunctional protein. Its activity, inside and outside cells, contributes to the biology of the brain, muscle, skin, and adipocyte tissues. Overexpression of S100B occurs in Down Syndrome, Alzheimer’s disease, Creutzfeldt–Jakob… read more here.
Keywords: extracellular s100b; rage receptor; nitrosylation; rage ... See more keywords