Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2020.101106
Abstract: Objective Skeletal muscle regeneration relies on muscle-specific adult stem cells (MuSCs), MuSC progeny, muscle progenitor cells (MPCs), and a coordinated myogenic program that is influenced by the extracellular environment. Following injury, MPCs undergo a transient… read more here.
Keywords: skeletal muscle; extracellular serine; glycine; serine glycine ... See more keywords
Extracellular serine feeds cancer skin stem cells
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/s41580-020-0261-9
Abstract: Premalignant skin stem cells become dependent on extracellular serine for proliferation, and this metabolic reprogramming inhibits tumour-suppressing cell differentiation. read more here.
Keywords: skin stem; stem cells; serine feeds; extracellular serine ... See more keywords
Extracellular serine empowers epidermal proliferation and psoriasis-like symptoms.
Sign Up to like & getrecommendations! Published in 2022 at "Science advances"
DOI: 10.1126/sciadv.abm7902
Abstract: The contribution of nutrient availability to control epidermal cell proliferation, inflammation, and hyperproliferative diseases remains unknown. Here, we studied extracellular serine and serine/glycine metabolism using human keratinocytes, human skin biopsies, and a mouse model of… read more here.
Keywords: cell; psoriasis like; proliferation; extracellular serine ... See more keywords