Super‐resolution shadow imaging reveals local remodeling of astrocytic microstructures and brain extracellular space after osmotic challenge
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.23995
Abstract: The extracellular space (ECS) plays a central role in brain physiology, shaping the time course and spread of neurochemicals, ions, and nutrients that ensure proper brain homeostasis and neuronal communication. Astrocytes are the most abundant… read more here.
Keywords: resolution; resolution shadow; shadow imaging; super resolution ... See more keywords
Honey, I shrunk the extracellular space: Measurements and mechanisms of astrocyte swelling
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24224
Abstract: Astrocyte volume fluctuation is a physiological phenomenon tied closely to the activation of neural circuits. Identification of underlying mechanisms has been challenging due in part to use of a wide range of experimental approaches that… read more here.
Keywords: astrocyte swelling; mechanisms astrocyte; volume; extracellular space ... See more keywords
Cellular mechanisms mediating activity‐dependent extracellular space shrinkage in the retina
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DOI: 10.1002/glia.24228
Abstract: Volume transmission plays an essential role in CNS function, with neurotransmitters released from synapses diffusing through the extracellular space (ECS) to distant sites. Changes in the ECS volume fraction (α) will influence the diffusion and… read more here.
Keywords: activity dependent; volume; extracellular space; activity ... See more keywords
Reduction of Dimensionality in Monte Carlo Simulation of Diffusion in Extracellular Space Surrounding Cubic Cells
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02793-6
Abstract: The real-time iontophoretic method has measured volume fraction and tortuosity of the interstitial component of extracellular space in many regions and under different conditions. To interpret these data computer models of the interstitial space (ISS)… read more here.
Keywords: extracellular space; monte carlo; space; reduction ... See more keywords
The olfactory stimulation slows down the substance clearance in the extracellular space of the hippocampus in rat brain.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.05.159
Abstract: Accelerating the clearance of toxin in the brain extracellular space (ECS) has grown a promising strategy for treating some central nervous system diseases. As oldest sensory system, we know little about the influence of olfaction… read more here.
Keywords: hippocampus; extracellular space; clearance; brain ... See more keywords
Alarmins of the extracellular space.
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in immunology"
DOI: 10.1016/j.smim.2018.08.004
Abstract: The ability of the immune system to discriminate between healthy-self, abnormal-self, and non-self has been attributed mainly to alarmins signaling as "danger signals". It is now evident, however, that alarmins are much more complex and… read more here.
Keywords: space; extracellular space; alarmins extracellular; localization ... See more keywords
Toward dynamic, anisotropic, high-resolution, and functional measurement in the brain extracellular space
Sign Up to like & getrecommendations! Published in 2022 at "Neurophotonics"
DOI: 10.1117/1.nph.9.3.032210
Abstract: Abstract. Diffusion of substances in the brain extracellular space (ECS) is important for extrasynaptic communication, extracellular ionic homeostasis, drug delivery, and metabolic waste clearance. However, substance diffusion is largely constrained by the geometry of brain… read more here.
Keywords: diffusion; measurement brain; brain; brain extracellular ... See more keywords
Thiol Modifications in the Extracellular Space—Key Proteins in Inflammation and Viral Infection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.932525
Abstract: Posttranslational modifications (PTMs) allow to control molecular and cellular functions in response to specific signals and changes in the microenvironment of cells. They regulate structure, localization, stability, and function of proteins in a spatial and… read more here.
Keywords: thiol; infection; extracellular space; modifications extracellular ... See more keywords
Potential of extracellular space for tissue regeneration in dentistry
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.1034603
Abstract: With the proven relationship between oral and general health and the growing aging population, it is pivotal to provide accessible therapeutic approaches to regenerate oral tissues and restore clinical function. However, despite sharing many core… read more here.
Keywords: tissue regeneration; extracellular space; medicine;
Is There a Role for Immunoregulatory and Antiviral Oligonucleotides Acting in the Extracellular Space? A Review and Hypothesis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232314593
Abstract: Here, we link approved and emerging nucleic acid-based therapies with the expanding universe of small non-coding RNAs (sncRNAs) and the innate immune responses that sense oligonucleotides taken up into endosomes. The Toll-like receptors (TLRs) 3,… read more here.
Keywords: immunoregulatory antiviral; review; extracellular space; nucleic acids ... See more keywords
Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.52160
Abstract: Neurons in developing sensory pathways exhibit spontaneous bursts of electrical activity that are critical for survival, maturation and circuit refinement. In the auditory system, intrinsically generated activity arises within the cochlea, but the molecular mechanisms… read more here.
Keywords: extracellular space; hair cell; purinergic signaling; supporting cells ... See more keywords