Extracellular tau oligomers affect extracellular glutamate handling by astrocytes through downregulation of GLT‐1 expression and impairment of NKA1A2 function
Sign Up to like & getrecommendations! Published in 2022 at "Neuropathology and Applied Neurobiology"
DOI: 10.1111/nan.12811
Abstract: Several studies reported that astrocytes support neuronal communication by the release of gliotransmitters, including ATP and glutamate. Astrocytes also play a fundamental role in buffering extracellular glutamate in the synaptic cleft, thus limiting the risk… read more here.
Keywords: glutamate; tau oligomers; oligomers affect; extracellular tau ... See more keywords
Dural lymphatics regulate clearance of extracellular tau from the CNS
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-019-0312-x
Abstract: BackgroundAlzheimer’s disease is characterized by two main neuropathological hallmarks: extracellular plaques of amyloid-β (Aβ) protein and intracellular aggregates of tau protein. Although tau is normally a soluble monomer that bind microtubules, in disease it forms… read more here.
Keywords: clearance extracellular; tau; pathology; cns ... See more keywords