Differential expression and analysis of extrachromosomal circular DNAs as serum biomarkers in lung adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of clinical laboratory analysis"
DOI: 10.1002/jcla.24425
Abstract: BACKGROUND Extrachromosomal circular DNAs (eccDNAs) increase the number of proto-oncogenes by enhancing oncogene expression to promote tumorigenesis. However, there are limited reports on differential eccDNA expression and analysis in lung cancer, especially in lung adenocarcinoma… read more here.
Keywords: expression; serum; circd; lad ... See more keywords
eccDNAdb: a database of extrachromosomal circular DNA profiles in human cancers
Sign Up to like & getrecommendations! Published in 2022 at "Oncogene"
DOI: 10.1038/s41388-022-02286-x
Abstract: Extrachromosomal circular DNA (eccDNA) elements are circular DNA molecules that are derived from but are independent of chromosomal DNA. EccDNA is emerging as a rising star because of its ubiquitous existence in cancers and its… read more here.
Keywords: dna; database; circular dna; eccdnadb database ... See more keywords
Duplication with structural modification through extrachromosomal circular and lariat DNA in the human genome
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-63665-6
Abstract: Duplication plays an important role in creating drastic changes in genome evolution. In addition to well-known tandem duplication, duplication can occur such that a duplicated DNA fragment is inserted at another location in the genome.… read more here.
Keywords: structural modification; dna fragment; duplication; dna ... See more keywords
eccDNA-pipe: an integrated pipeline for identification, analysis and visualization of extrachromosomal circular DNA from high-throughput sequencing data
Sign Up to like & getrecommendations! Published in 2024 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbae034
Abstract: Abstract Extrachromosomal circular DNA (eccDNA) is currently attracting considerable attention from researchers due to its significant impact on tumor biogenesis. High-throughput sequencing (HTS) methods for eccDNA identification are continually evolving. However, an efficient pipeline for… read more here.
Keywords: extrachromosomal circular; pipeline; analysis; identification ... See more keywords
Extrachromosomal circular DNA mediated spread of herbicide resistance in interspecific hybrids of pigweed.
Sign Up to like & getrecommendations! Published in 2023 at "Plant physiology"
DOI: 10.1093/plphys/kiad281
Abstract: Extrachromosomal circular DNAs (eccDNAs) are found in many eukaryotic organisms. EccDNA-powered copy number variation plays diverse roles, from oncogenesis in humans to herbicide resistance in crop weeds. Here, we report interspecific eccDNA flow and its… read more here.
Keywords: circular dna; eccdna replicon; resistance; dna mediated ... See more keywords
Innovative insights into extrachromosomal circular DNAs in gynecologic tumors and reproduction.
Sign Up to like & getrecommendations! Published in 2023 at "Protein & cell"
DOI: 10.1093/procel/pwad032
Abstract: Originating but free from chromosomal DNA, extrachromosomal circular DNAs (eccDNAs) are organized in circular form and have long been found in unicellular and multicellular eukaryotes. Their biogenesis and function are poorly understood as they are… read more here.
Keywords: innovative insights; gynecologic tumors; tumors reproduction; circular dnas ... See more keywords
Extrachromosomal circular MiR-17-92 amplicon promotes hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000435
Abstract: BACKGROUND AND AIMS Extrachromosomal circular DNAs (eccDNAs) are prevalent in cancer genomes and emerge as a class of crucial yet less characterized oncogenic drivers. However, the structure, composition, genome-wide frequency, and contribution of eccDNAs in… read more here.
Keywords: hepatocellular carcinoma; hcc; mir; microrna containing ... See more keywords
Characterization of extrachromosomal circular DNA in cattle using 676 whole genome sequencing datasets.
Sign Up to like & getrecommendations! Published in 2022 at "Animal genetics"
DOI: 10.1111/age.13269
Abstract: Extrachromosomal circular DNA (eccDNA) is an important fraction of the genome. Recent studies proved that eccDNA plays important roles in genetic variation, aging and environmental adaptation, which have drawn wide attention. However, the characteristics of… read more here.
Keywords: circular dna; dna; genome sequencing; genome ... See more keywords
Extrachromosomal Circular DNA in Cancer: Mechanisms and Clinical Applications
Sign Up to like & getrecommendations! Published in 2025 at "Cell Proliferation"
DOI: 10.1111/cpr.70040
Abstract: Extrachromosomal circular DNA (eccDNA) has emerged as a critical area of cancer research due to its ubiquitous presence in tumour cells and significant role in tumorigenesis, progression and drug resistance. Recent studies demonstrate that eccDNA… read more here.
Keywords: cancer; extrachromosomal circular; dna cancer; cancer mechanisms ... See more keywords
Extrachromosomal Circular DNA: A Mobile Genetic Element Shaping Host Biology.
Sign Up to like & getrecommendations! Published in 2025 at "Annual review of cell and developmental biology"
DOI: 10.1146/annurev-cellbio-101323-124454
Abstract: DNA carries genetic information, ensuring the stable transmission of genetic material through generations. However, DNA sequences can be constantly rewritten, allowing evolution and adaptation to occur at both the cellular and species levels. To facilitate… read more here.
Keywords: extrachromosomal circular; biology; mobile genetic; circular dna ... See more keywords
Differential expression and analysis of extrachromosomal circular DNAs as serum biomarkers in pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2024 at "Respiratory Research"
DOI: 10.1186/s12931-024-02808-z
Abstract: Background Extrachromosomal circular DNAs (eccDNAs) have been reported to play a key role in the occurrence and development of various diseases. However, the characterization and role of eccDNAs in pulmonary arterial hypertension (PAH) remain unclear.… read more here.
Keywords: extrachromosomal circular; arterial hypertension; analysis; circular dnas ... See more keywords