Differential expression and analysis of extrachromosomal circular DNAs as serum biomarkers in lung adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of clinical laboratory analysis"
DOI: 10.1002/jcla.24425
Abstract: BACKGROUND Extrachromosomal circular DNAs (eccDNAs) increase the number of proto-oncogenes by enhancing oncogene expression to promote tumorigenesis. However, there are limited reports on differential eccDNA expression and analysis in lung cancer, especially in lung adenocarcinoma… read more here.
Keywords: expression; serum; circd; lad ... See more keywords
eccDNAdb: a database of extrachromosomal circular DNA profiles in human cancers
Sign Up to like & getrecommendations! Published in 2022 at "Oncogene"
DOI: 10.1038/s41388-022-02286-x
Abstract: Extrachromosomal circular DNA (eccDNA) elements are circular DNA molecules that are derived from but are independent of chromosomal DNA. EccDNA is emerging as a rising star because of its ubiquitous existence in cancers and its… read more here.
Keywords: dna; database; circular dna; eccdnadb database ... See more keywords
Duplication with structural modification through extrachromosomal circular and lariat DNA in the human genome
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-63665-6
Abstract: Duplication plays an important role in creating drastic changes in genome evolution. In addition to well-known tandem duplication, duplication can occur such that a duplicated DNA fragment is inserted at another location in the genome.… read more here.
Keywords: structural modification; dna fragment; duplication; dna ... See more keywords
Extrachromosomal circular DNA mediated spread of herbicide resistance in interspecific hybrids of pigweed.
Sign Up to like & getrecommendations! Published in 2023 at "Plant physiology"
DOI: 10.1093/plphys/kiad281
Abstract: Extrachromosomal circular DNAs (eccDNAs) are found in many eukaryotic organisms. EccDNA-powered copy number variation plays diverse roles, from oncogenesis in humans to herbicide resistance in crop weeds. Here, we report interspecific eccDNA flow and its… read more here.
Keywords: circular dna; eccdna replicon; resistance; dna mediated ... See more keywords
Innovative insights into extrachromosomal circular DNAs in gynecologic tumors and reproduction.
Sign Up to like & getrecommendations! Published in 2023 at "Protein & cell"
DOI: 10.1093/procel/pwad032
Abstract: Originating but free from chromosomal DNA, extrachromosomal circular DNAs (eccDNAs) are organized in circular form and have long been found in unicellular and multicellular eukaryotes. Their biogenesis and function are poorly understood as they are… read more here.
Keywords: innovative insights; gynecologic tumors; tumors reproduction; circular dnas ... See more keywords
Extrachromosomal circular MiR-17-92 amplicon promotes hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000435
Abstract: BACKGROUND AND AIMS Extrachromosomal circular DNAs (eccDNAs) are prevalent in cancer genomes and emerge as a class of crucial yet less characterized oncogenic drivers. However, the structure, composition, genome-wide frequency, and contribution of eccDNAs in… read more here.
Keywords: hepatocellular carcinoma; hcc; mir; microrna containing ... See more keywords
Characterization of extrachromosomal circular DNA in cattle using 676 whole genome sequencing datasets.
Sign Up to like & getrecommendations! Published in 2022 at "Animal genetics"
DOI: 10.1111/age.13269
Abstract: Extrachromosomal circular DNA (eccDNA) is an important fraction of the genome. Recent studies proved that eccDNA plays important roles in genetic variation, aging and environmental adaptation, which have drawn wide attention. However, the characteristics of… read more here.
Keywords: circular dna; dna; genome sequencing; genome ... See more keywords
Identification and Characterization of Extrachromosomal Circular DNA in Plasma of Lung Adenocarcinoma Patients
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s363425
Abstract: Background Chromosome is the basic framework for eukaryotic cells to store genetic information, but certain genes exist in circulation, such as extrachromosomal circular DNA (eccDNA). The unique genetic characteristics and structure of eccDNA provide a… read more here.
Keywords: lung adenocarcinoma; eccdna; lung; adenocarcinoma patients ... See more keywords
Extrachromosomal Circular DNA (eccDNA): From Chaos to Function
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.792555
Abstract: Extrachromosomal circular DNA (eccDNA) is a type of double-stranded circular DNA that is derived and free from chromosomes. It has a strong heterogeneity in sequence, length, and origin and has been identified in both normal… read more here.
Keywords: circular dna; eccdna chaos; eccdna; dna eccdna ... See more keywords
Characterization of Plasma Extrachromosomal Circular DNA in Gouty Arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.859513
Abstract: Objective: Extrachromosomal circular DNA elements (eccDNAs) are known for their broad existence in cells and plasma, which may potentially play important roles in many biological processes. Our aim was to identify potentially functional or marked… read more here.
Keywords: gout; circular dna; gouty arthritis; extrachromosomal circular ... See more keywords
Identification and characterization of extrachromosomal circular DNA in alcohol induced osteonecrosis of femoral head
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.918379
Abstract: Alcohol-induced osteonecrosis of the femoral head (AIONFH) is a complicated refractory bone disease seen in the clinic. The pathogenesis of AIONFH is still controversial. Extrachromosomal circular DNA (eccDNA) elements have been indicated ubiquitously exist in… read more here.
Keywords: femoral head; induced osteonecrosis; dna; alcohol induced ... See more keywords