Mapping the Single Origin of Replication in the Naegleria gruberi Extrachromosomal DNA Element.
Sign Up to like & getrecommendations! Published in 2019 at "Protist"
DOI: 10.1016/j.protis.2019.02.001
Abstract: The genes encoding the ribosomal RNA (rRNA) subunits of the amoeba Naegleria gruberi are encoded in a relatively uncommon arrangement: on a circular extrachromosomal DNA element with each organism carrying about 4,000 copies of the… read more here.
Keywords: dna; replication; dna element; naegleria gruberi ... See more keywords
Resolving spatial subclonal genomic heterogeneity of loss of heterozygosity and extrachromosomal DNA in gliomas
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DOI: 10.1038/s41467-025-59805-z
Abstract: Mapping the spatial organization of DNA-level somatic copy number changes in tumors can provide insight to understanding higher-level molecular and cellular processes that drive pathogenesis. We describe an integrated framework of spatial transcriptomics, tumor/normal DNA… read more here.
Keywords: loss heterozygosity; tumor; extrachromosomal dna; heterogeneity ... See more keywords
Origins and impact of extrachromosomal DNA
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DOI: 10.1038/s41586-024-08107-3
Abstract: Extrachromosomal DNA (ecDNA) is a major contributor to treatment resistance and poor outcome for patients with cancer1,2. Here we examine the diversity of ecDNA elements across cancer, revealing the associated tissue, genetic and mutational contexts.… read more here.
Keywords: cancer; tissue; dna; extrachromosomal dna ... See more keywords
METB-08. CIRCULAR EXTRACHROMOSOMAL DNA IS ASSOCIATED WITH POOR SURVIVAL IN CHILDHOOD CANCER TYPES
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DOI: 10.1093/neuonc/noae064.249
Abstract: Abstract BACKGROUND Circular extrachromosomal DNA (ecDNA) is a common form of oncogene amplification in aggressive cancers and a promising target for improved cancer therapy. The frequency and diversity of ecDNA has been described in different… read more here.
Keywords: cancer; childhood; survival; extrachromosomal dna ... See more keywords
STEM-07. CONSERVATION AND FAITHFUL REPRESENTATION OF CIRCULAR EXTRACHROMOSOMAL DNA IN ORTHOTOPIC PATIENT-DERIVED MEDULLOBLASTOMA XENOGRAFTS
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DOI: 10.1093/neuonc/noae064.778
Abstract: Abstract BACKGROUND Extrachromosomal DNA (ecDNA) drives tumor heterogeneity and correlates with poor survival across various cancer types. Patient-derived xenograft (PDX) models facilitate preclinical drug testing in vivo, enabling tumor growth analysis and molecular tumor profiling.… read more here.
Keywords: conservation; ecdna; pdx; tumor ... See more keywords
TMIC-26. Intercellular transfer of extrachromosomal DNA in glioblastoma
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.1781
Abstract: Glioblastoma (GBM) represent a complex ecosystem of intertwined interconnections between various cell types. Through diverse mechanisms of intercellular communication, GBM cells can modulate the behavior of both malignant and non-tumor cells, promoting cancer progression. One… read more here.
Keywords: gbm cells; ecdna; tumor; transfer ... See more keywords
PopRice extrachromosomal DNA sponges ABSCISIC ACID-INSENSITIVE 5 in rice seed-to-seedling transition.
Sign Up to like & getrecommendations! Published in 2023 at "Plant physiology"
DOI: 10.1093/plphys/kiad071
Abstract: Extrachromosomal DNA produced by a retrotransposon PopRice mediates gibberellin-abscisic acid antagonism in seed-to-seedling transition of rice by sponging the transcription factor OsABI5. read more here.
Keywords: seed seedling; abscisic acid; extrachromosomal dna; seed ... See more keywords
Abstract 3130: Extrachromosomal DNA in the cancerous transformation of Barrett’s esophagus
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DOI: 10.1158/1538-7445.am2023-3130
Abstract: Oncogene amplification on extrachromosomal DNA (ecDNA) drives rapid tumor evolution, treatment resistance, and poor outcomes for patients. Computational tools can detect ecDNA in whole-genome sequencing (WGS) data from biopsies. However, the lack of longitudinal studies… read more here.
Keywords: barrett esophagus; cancer; ecdna; extrachromosomal dna ... See more keywords
Abstract 3755: AmpliconSuite enables discovery of extrachromosomal DNA in tumor genomes
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-3755
Abstract: Focal amplifications in the cancer genome, particularly extrachromosomal DNA (ecDNA) amplifications, are a pivotal event in cancer progression across diverse cancer contexts. These megabase-scale circular structures arise when DNA breaks off chromosomes, accumulating hundreds of… read more here.
Keywords: cancer; tumor; extrachromosomal dna; enables discovery ... See more keywords
Abstract IA017: Extrachromosomal DNA (ecDNA): Cancer’s dynamic circular genome
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DOI: 10.1158/1538-7445.canevol23-ia017
Abstract: Human genes are arranged on 23 pairs of chromosomes, but in cancer, tumor-promoting genes and regulatory elements can free themselves from chromosomes and relocate to circular, extrachromosomal pieces of DNA (ecDNA). ecDNA poses one of… read more here.
Keywords: cancer; cancer dynamic; dna ecdna; ecdna ... See more keywords
Oncogene Convergence in Extrachromosomal DNA Hubs
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DOI: 10.1158/2159-8290.cd-22-0076
Abstract: Summary: Extrachromosomal DNA circles (ecDNA) are a common mechanism for oncogene amplification and are associated with worse clinical outcomes compared with other types of oncogene amplification. Several recent discoveries of ecDNA hubs—local congregations of ecDNAs… read more here.
Keywords: convergence extrachromosomal; dna; dna hubs; oncogene convergence ... See more keywords