Mapping the Single Origin of Replication in the Naegleria gruberi Extrachromosomal DNA Element.
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DOI: 10.1016/j.protis.2019.02.001
Abstract: The genes encoding the ribosomal RNA (rRNA) subunits of the amoeba Naegleria gruberi are encoded in a relatively uncommon arrangement: on a circular extrachromosomal DNA element with each organism carrying about 4,000 copies of the… read more here.
Keywords: dna; replication; dna element; naegleria gruberi ... See more keywords
PopRice extrachromosomal DNA sponges ABSCISIC ACID-INSENSITIVE 5 in rice seed-to-seedling transition.
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DOI: 10.1093/plphys/kiad071
Abstract: Extrachromosomal DNA produced by a retrotransposon PopRice mediates gibberellin-abscisic acid antagonism in seed-to-seedling transition of rice by sponging the transcription factor OsABI5. read more here.
Keywords: seed seedling; abscisic acid; extrachromosomal dna; seed ... See more keywords
Abstract 3130: Extrachromosomal DNA in the cancerous transformation of Barrett’s esophagus
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DOI: 10.1158/1538-7445.am2023-3130
Abstract: Oncogene amplification on extrachromosomal DNA (ecDNA) drives rapid tumor evolution, treatment resistance, and poor outcomes for patients. Computational tools can detect ecDNA in whole-genome sequencing (WGS) data from biopsies. However, the lack of longitudinal studies… read more here.
Keywords: barrett esophagus; cancer; ecdna; extrachromosomal dna ... See more keywords
Oncogene Convergence in Extrachromosomal DNA Hubs
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DOI: 10.1158/2159-8290.cd-22-0076
Abstract: Summary: Extrachromosomal DNA circles (ecDNA) are a common mechanism for oncogene amplification and are associated with worse clinical outcomes compared with other types of oncogene amplification. Several recent discoveries of ecDNA hubs—local congregations of ecDNAs… read more here.
Keywords: convergence extrachromosomal; dna; dna hubs; oncogene convergence ... See more keywords
Oncogene Amplification on Extrachromosomal DNA Is Common in Cancer.
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DOI: 10.1158/2159-8290.cd-rw2020-126
Abstract: Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers. read more here.
Keywords: oncogene amplification; extrachromosomal dna; amplification extrachromosomal; cancer ... See more keywords
Pioneering insights of extrachromosomal DNA (ecDNA) generation, action and its implications for cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.73479
Abstract: Extrachromosomal DNA (ecDNA) is a cancer-specific circular DNA molecule that is derived from chromosomes. In contrast with linear chromosomes, ecDNA exhibits a unique structure that can be representative of high chromosome accessibility, contributing to hyperactivated… read more here.
Keywords: dna; ecdna; dna ecdna; pioneering insights ... See more keywords