Results of ARI‐0001 CART19 cell therapy in patients with relapsed/refractory CD19‐positive acute lymphoblastic leukemia with isolated extramedullary disease
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26519
Abstract: We evaluated outcomes of 18 patients with isolated extramedullary disease (iEMD) relapsed/refractory (R/R) B‐cell acute lymphoblastic leukemia (B‐ALL) treated with the CD19‐directed CAR T cells ARI‐0001 in two centers (adult and pediatric), including patients treated… read more here.
Keywords: relapsed refractory; isolated extramedullary; extramedullary disease; lymphoblastic leukemia ... See more keywords
Extramedullary disease in multiple myeloma: a systematic literature review.
Sign Up to like & getrecommendations! Published in 2022 at "Blood cancer journal"
DOI: 10.1038/s41408-022-00643-3
Abstract: Extramedullary involvement (or extramedullary disease, EMD) represents an aggressive form of multiple myeloma (MM), characterized by the ability of a clone and/or subclone to thrive and grow independent of the bone marrow microenvironment. Several different… read more here.
Keywords: reported incidence; involvement; multiple myeloma; extramedullary disease ... See more keywords
Clinical characteristics and prognosis of multiple myeloma with bone-related extramedullary disease at diagnosis
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DOI: 10.1042/bsr20171697
Abstract: Multiple myeloma (MM) is a hematological neoplasm which results in diffuse or focal bone infiltration and extramedullary lesions. It’s reported that infiltration of organs by plasma cells indicated worse prognosis, but the prognosis of patients… read more here.
Keywords: bone related; prognosis; multiple myeloma; related extramedullary ... See more keywords
Extramedullary disease at diagnosis of AML does not influence outcome of patients undergoing allogeneic hematopoietic cell transplant in CR1
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Haematology"
DOI: 10.1111/ejh.12909
Abstract: Extramedullary disease (EMD) at diagnosis of acute myeloid leukemia (AML) has been associated with increased risk of relapse and worse outcomes post‐chemotherapy. This study sought to investigate the association of EMD with outcomes following allogeneic… read more here.
Keywords: hematopoietic cell; extramedullary disease; allogeneic hematopoietic; diagnosis ... See more keywords
Lysyl oxidase expression is associated with inferior outcome and Extramedullary disease of acute myeloid leukemia
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DOI: 10.1186/s40364-020-00200-9
Abstract: Background Lysyl oxidase (LOX) has been described as necessary for premetastatic niche formation in epithelium-derived malignancies and its expression level therefore correlates with risk of metastatic disease and overall survival. However, its role in acute… read more here.
Keywords: extramedullary disease; group; lysyl oxidase; expression ... See more keywords
Outcome of relapsed or refractory acute B-lymphoblastic leukemia patients and BCR-ABL-positive blast cell crisis of B-lymphoid lineage with extramedullary disease receiving inotuzumab ozogamicin
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DOI: 10.3324/haematol.2021.280433
Abstract: Acute lymphoblastic leukemia (ALL) can relapse in the extramedullary compartment, with or without medullary involvement. Response to treatment may be individual. We evaluated response to inotuzumab ozogamicin in 31 patients with relapsed/refractory B-ALL with extramedullary… read more here.
Keywords: disease; relapsed refractory; extramedullary disease; lymphoblastic leukemia ... See more keywords
A prognostic model for patients with primary extramedullary multiple myeloma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1021587
Abstract: Background: Extramedullary disease is a manifestation of multiple myeloma, the prognosis of which remains poor even in the era of novel drugs. Therefore, we aimed to develop a predictive model for patients with primary extramedullary… read more here.
Keywords: extramedullary disease; model patients; multiple myeloma; model ... See more keywords
Efficacy of Humanized Anti-BCMA CAR T Cell Therapy in Relapsed/Refractory Multiple Myeloma Patients With and Without Extramedullary Disease
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.720571
Abstract: In recent years, many new treatments for relapsed/refractory (R/R) multiple myeloma (MM) have improved patient prognosis, but the prognosis of patients with extramedullary MM is still particularly poor. Therefore, more efficacious therapies and novel strategies… read more here.
Keywords: patients extramedullary; car cell; without extramedullary; disease ... See more keywords
68Ga-Pentixafor PET/CT May Fail to Detect Recurrent Multiple Myeloma with Extramedullary Disease
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DOI: 10.3390/diagnostics13050871
Abstract: Two patients with a history of multiple myeloma experienced a recurrence of the disease.18F-FDG PET/CT revealed prominent extramedullary disease as well as multi-foci in the bone marrow, both with increased FDG uptake. However, on 68Ga-Pentixafor… read more here.
Keywords: 68ga pentixafor; pet; myeloma; extramedullary disease ... See more keywords