Extrapolation of Midazolam Disposition in Neonates Using Physiological‐Based Pharmacokinetic/Pharmacodynamic Modeling
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1531
Abstract: There is a shortage of data in clinical studies of neonatal populations, which often utilize extrapolation strategies and model simulation techniques to support drug development and clinical applications. This study established an adult physiological‐based pharmacokinetic/pharmacodynamic… read more here.
Keywords: neonates using; based pharmacokinetic; physiological based; extrapolation ... See more keywords
In vitro to in vivo extrapolation of biotransformation rates for assessing bioaccumulation of hydrophobic organic chemicals in mammals.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.3718
Abstract: Incorporating biotransformation in bioaccumulation assessments of hydrophobic chemicals in both aquatic and terrestrial organisms in a simple, rapid, and cost-effective manner is urgently needed to improve bioaccumulation assessments of potentially bioaccumulative substances. One approach to… read more here.
Keywords: rate constants; extrapolation; biotransformation; hydrophobic ... See more keywords
Reliable and Representative Estimation of Extrapolation Model Application in Deriving Water Quality Criteria for Antibiotics
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology and Chemistry"
DOI: 10.1002/etc.5512
Abstract: Deriving water quality benchmarks based on the species sensitivity distribution (SSD) is crucial for assessing the ecological risks of antibiotics. The application of extrapolation methods such as interspecies correlation estimation (ICE) and acute‐to‐chronic ratios (ACRs)… read more here.
Keywords: deriving water; extrapolation; water quality; toxicity ... See more keywords
A proximal difference-of-convex algorithm with extrapolation
Sign Up to like & getrecommendations! Published in 2018 at "Computational Optimization and Applications"
DOI: 10.1007/s10589-017-9954-1
Abstract: We consider a class of difference-of-convex (DC) optimization problems whose objective is level-bounded and is the sum of a smooth convex function with Lipschitz gradient, a proper closed convex function and a continuous concave function.… read more here.
Keywords: difference convex; dca; extrapolation; convex ... See more keywords
Resolution Enhancement in Terahertz Digital In-line Holography by Sparsity-Based Extrapolation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Infrared, Millimeter, and Terahertz Waves"
DOI: 10.1007/s10762-021-00796-5
Abstract: We introduce a generalized extrapolation framework as a constrained optimization problem to enhance the resolution in terahertz digital in-line holography. The alternating minimization method is employed to iteratively extrapolate the hologram beyond the actually detecting… read more here.
Keywords: resolution; sparsity based; extrapolation; line holography ... See more keywords
Synergism of spectra averaging and extrapolation for quantification of in vivo MRS time signals encoded from the ovary
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Mathematical Chemistry"
DOI: 10.1007/s10910-016-0728-2
Abstract: The fast Padé transform (FPT) is further optimized for encoded in vivo MRS time signals. This is achieved by a judicious combination of spectra averaging and time signal extrapolation. The motivation is in strengthening suppression… read more here.
Keywords: spectra averaging; time; extrapolation; vivo mrs ... See more keywords
On an extrapolation problem for characteristic functions
Sign Up to like & getrecommendations! Published in 2020 at "Lithuanian Mathematical Journal"
DOI: 10.1007/s10986-020-09485-7
Abstract: Let f be the characteristic function of a probability measure μ f on ℝ n , and let σ > 0. We study the following extrapolation problem: under what conditions on the neighborhood of infinity… read more here.
Keywords: characteristic functions; extrapolation problem; extrapolation; problem characteristic ... See more keywords
Extrapolation is not the same as interpolation
Sign Up to like & getrecommendations! Published in 2024 at "Machine Learning"
DOI: 10.1007/s10994-024-06591-2
Abstract: We propose a new machine learning formulation designed specifically for extrapolation. The textbook way to apply machine learning to drug design is to learn a univariate function that when a drug (structure) is input, the… read more here.
Keywords: formulation; drug design; extrapolation; usepackage ... See more keywords
Extrapolation-Based Regionalized Re-evaluation of the Global Estuarine Surface Area
Sign Up to like & getrecommendations! Published in 2024 at "Estuaries and Coasts"
DOI: 10.1007/s12237-024-01463-3
Abstract: At the interface between the continental and oceanic domains, estuaries are essential components of the land–ocean aquatic continuum. These coastal ecosystems play a significant role in biogeochemical cycles, as they transform and export large amounts… read more here.
Keywords: estuarine surface; surface area; global estuarine; extrapolation ... See more keywords
Extrapolation of load spectra by optimized Kernel Density Estimators using Monte-Carlo-Simulation
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Fatigue"
DOI: 10.1016/j.ijfatigue.2021.106182
Abstract: Abstract In the present article a method based on Monte Carlo Simulation (MCS) is developed with which any spectrum extrapolation method can be statistically evaluated. Thereby, the duration of service life spectrum and the extrapolation… read more here.
Keywords: monte carlo; extrapolation; kernel density; carlo simulation ... See more keywords
Methods for Spatial Extrapolation of Methane Measurements in Constructing Regional Estimates from Sample Populations
Sign Up to like & getrecommendations! Published in 2024 at "Environmental Science & Technology"
DOI: 10.1021/acs.est.3c08185
Abstract: Methane emission estimates for oil and gas facilities are typically based on estimates at a subpopulation of facilities, and these emission estimates are then extrapolated to a larger region or basin. Basin-level emission estimates are… read more here.
Keywords: basin; emission estimates; extrapolation; methane ... See more keywords