The Acceptance of Overall Survival Extrapolation Methods in Solid Tumor Treatments by Health Technology Assessment Agencies in England, France, and Australia between 2017 and 2022
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DOI: 10.1177/0272989x251351635
Abstract: Background Survival extrapolation is used to predict patients’ overall survival beyond clinical trial follow-up. It can significantly affect the results of a cost-effectiveness analysis and subsequent pricing and reimbursement decisions. However, selecting an appropriate model… read more here.
Keywords: extrapolation; survival extrapolation; acceptance; overall survival ... See more keywords
Comparison of absorbed dose extrapolation methods for mouse-to-human translation of radiolabelled macromolecules
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DOI: 10.1186/s13550-022-00893-z
Abstract: Background Extrapolation of human absorbed doses (ADs) from biodistribution experiments on laboratory animals is used to predict the efficacy and toxicity profiles of new radiopharmaceuticals. Comparative studies between available animal-to-human dosimetry extrapolation methods are missing.… read more here.
Keywords: extrapolation; organ specific; extrapolation methods; nodaga rgdyk ... See more keywords