Spontaneous and emergent extrapyramidal syndromes in Black Africans with first-episode schizophrenia and first exposure to antipsychotics
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Mental Health"
DOI: 10.1080/09638237.2020.1739242
Abstract: Abstract Background Persons of African ancestry are thought to carry a higher risk for extrapyramidal syndromes (EPS) in schizophrenia. Aim We investigated the phenomenon of spontaneous and treatment-emergent EPS in a sample comprising Xhosa (South… read more here.
Keywords: schizophrenia; africans first; treatment; treatment emergent ... See more keywords
Ascorbic acid improves extrapyramidal syndromes and corpus striatal degeneration induced by dopamine-2 receptor inhibition in Wistar rats.
Sign Up to like & getrecommendations! Published in 2020 at "Drug metabolism and personalized therapy"
DOI: 10.1515/dmdi-2020-0137
Abstract: Objectives The prolonged uses of fourth-generation antipsychotics have been implicated in inducing extrapyramidal syndromes characterized by the motor deficit. This was attributed to the loss of dopamine-2 receptor (D2R) signaling. However, ascorbic acid (SVCT2R stimulation)… read more here.
Keywords: wistar rats; extrapyramidal syndromes; inhibition; ascorbic acid ... See more keywords