Integrated metabolomics reveals altered lipid metabolism in adipose tissue in a model of extreme longevity
Sign Up to like & getrecommendations! Published in 2020 at "GeroScience"
DOI: 10.1007/s11357-020-00221-0
Abstract: Adipose tissue plays an essential role in metabolic health. Ames dwarf mice are exceptionally long-lived and display metabolically beneficial phenotypes in their adipose tissue, providing an ideal model for studying the intersection between adipose tissue… read more here.
Keywords: ames dwarf; extreme longevity; tissue; model extreme ... See more keywords
Physiological mechanisms underlying extreme longevity in mountain pine trees.
Sign Up to like & getrecommendations! Published in 2022 at "Plant physiology"
DOI: 10.1093/plphys/kiac540
Abstract: Ancient trees are life history longevity winners that mostly persist in remote and environmentally harsh mountainous areas. Here, we performed a multifeature analysis in a protected mature mountain pine (Pinus uncinata) forest to identify the… read more here.
Keywords: longevity; mountain pine; physiology; underlying extreme ... See more keywords
Phenotypic upregulation of hexocylceramides and ether‐linked phosphocholines as markers of human extreme longevity
Sign Up to like & getrecommendations! Published in 2024 at "Aging Cell"
DOI: 10.1111/acel.14429
Abstract: Centenarians and their relatives possess a notable survival advantage, with higher longevity and reduced susceptibility to major age‐related diseases. To date, characteristic omics profiles of centenarians have been described, demonstrating that these individuals with exceptional… read more here.
Keywords: ether linked; phenotypic upregulation; genetics; extreme longevity ... See more keywords
Immune-Inflammatory Response in Lifespan—What Role Does It Play in Extreme Longevity? A Sicilian Semi- and Supercentenarians Study
Sign Up to like & getrecommendations! Published in 2024 at "Biology"
DOI: 10.3390/biology13121010
Abstract: Simple Summary By analyzing inflammatory scores (INFLA-score, Systemic Inflammation Response Index—SIRI) and the Aging-Related Immune Phenotype (ARIP) in 249 participants aged 19–111 years, this study investigates the role of immune-inflammatory responses in semi- and supercentenarians… read more here.
Keywords: semi supercentenarians; role; response; immune inflammatory ... See more keywords
A Genome-Wide Association Study of 2304 Extreme Longevity Cases Identifies Novel Longevity Variants
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010116
Abstract: We performed a genome-wide association study (GWAS) of human extreme longevity (EL), defined as surviving past the 99th survival percentile, by aggregating data from four centenarian studies. The combined data included 2304 EL cases and… read more here.
Keywords: longevity; genome wide; association study; wide association ... See more keywords
Polypharmacy and Therapeutic Inertia in Extreme Longevity: A Potential Clinical Ageism Scenario Secondary to Important Gaps in Clinical Evidence
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Preventive Medicine and Public Health"
DOI: 10.3961/jpmph.24.364
Abstract: Population aging is a global health priority due to the dramatic increase in the proportion of older persons worldwide. It is also expected that both global life expectancy and disability-free life expectancy will increase, leading… read more here.
Keywords: polypharmacy; therapeutic inertia; clinical evidence; extreme longevity ... See more keywords