Discovery and development of extreme selective inhibitors of the ITD and D835Y mutant FLT3 kinases.
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DOI: 10.1016/j.ejmech.2019.111710
Abstract: Aberrant activation of FMS-like tyrosine receptor kinase 3 (FLT3) is implicated in the pathogenesis of acute myeloid leukemia (AML) in 20-30% of patients. In this study we identified a highly selective (phenylethenyl)quinazoline compound family as… read more here.
Keywords: development extreme; discovery development; flt3; extreme selective ... See more keywords