Water-soluble and -insoluble polymers as binders for pellet preparation by extrusion/spheronization
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2018.10.030
Abstract: Abstract The objective of this study was to investigate the effect of binder (water-soluble vs. -insoluble) and granulation fluid (aqueous vs. organic) on the physical properties of pellet prepared by extrusion/spheronization and on drug release.… read more here.
Keywords: release; extrusion spheronization; water; granulation fluid ... See more keywords
Optimized flurbiprofen sustained-release matrix pellets prepared by extrusion/spheronization
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2020.101902
Abstract: Abstract Flurbiprofen (FBP) is an ibuprofen derivative with less gastric side effects and short biological half-life (4.7–5.7 h). The study aimed to formulate FBP as a sustained-release pellets by extrusion/spheronization to overcome its short half-life and… read more here.
Keywords: sustained release; extrusion spheronization; mean line; line torque ... See more keywords
Preparation and in vitro characterization of carvacrol pellets by combination of liquisolid technique and extrusion-spheronization
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2020.102232
Abstract: Abstract Objective Carvacrol is one of the main pharmacologically active components of Thymus vulgaris essential oil, which has shown several therapeutic effects. Because of liquid nature of the carvacrol, the formulation of the drug is… read more here.
Keywords: technique; extrusion spheronization; carvacrol; preparation ... See more keywords
Mucoadhesive Properties of Thiolated Pectin-Based Pellets Prepared by Extrusion-Spheronization Technique.
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DOI: 10.1016/j.xphs.2017.01.028
Abstract: The aim of this study was to develop mucoadhesive pellets on a thiolated pectin base using the extrusion-spheronization technique. Thiolation of pectin was performed by esterification with thioglycolic acid. The molecular weight and thiol group… read more here.
Keywords: thiolated pectin; spheronization technique; pectin; extrusion spheronization ... See more keywords
Extrusion-Spheronization of UiO-66 and UiO-66_NH2 into Robust-Shaped Solids and Their Use for Gaseous Molecular Iodine, Xenon, and Krypton Adsorption.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c21380
Abstract: The use of an extrusion-spheronization process was investigated to prepare robust and highly porous extrudates and granules starting from UiO-66 and UiO-66_NH2 metal-organic framework powders. As-produced materials were applied to the capture of gaseous iodine… read more here.
Keywords: xenon krypton; extrusion spheronization; uio nh2;
Preparation of benznidazole pellets for immediate drug delivery using the extrusion spheronization technique
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DOI: 10.1080/03639045.2016.1220574
Abstract: Abstract Recent advances in the treatment of Chagas disease have followed combinations of drugs that act synergistically against infection, predominantly including benznidazole (BNZ) and azoles derivatives. Possible incompatibilities between these drugs, slow dissolution of BNZ… read more here.
Keywords: using extrusion; immediate drug; sodium; drug ... See more keywords
AN OUTLINE OF VARIABLES IN PELLETIZATION BY EXTRUSION AND SPHERONIZATION
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DOI: 10.22159/ijap.2020v12i4.37277
Abstract: Pelletization is an agglomeration process which converts fine granules or powders of bulk drugs into small, free-flowing, spherical units, known as pellets. The pelletization can be achieved either through agitation, compaction (extrusion-spheronization), drug layering and… read more here.
Keywords: process; extrusion spheronization; outline variables; pelletization ... See more keywords