Pharmacokinetic Interaction Between Telmisartan and Rosuvastatin/Ezetimibe After Multiple Oral Administration in Healthy Subjects
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DOI: 10.1007/s12325-020-01592-8
Abstract: Telmisartan, rosuvastatin and ezetimibe are commonly recommended as combination therapies. However, the pharmacokinetic (PK) interaction among these therapeutic drugs has not been clearly reported. The objective of this study was to investigate possible interactions between… read more here.
Keywords: pharmacokinetic interaction; rosuvastatin ezetimibe; telmisartan rosuvastatin; rosuvastatin ... See more keywords
Enzymatic synthesis of an ezetimibe intermediate using carbonyl reductase coupled with glucose dehydrogenase in an aqueous-organic solvent system.
Sign Up to like & getrecommendations! Published in 2017 at "Bioresource technology"
DOI: 10.1016/j.biortech.2016.12.098
Abstract: (4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one ((S)-ET-5) is an important chiral intermediate in the synthesis of chiral side chain of ezetimibe. Recombinant Escherichia coli expressing carbonyl reductase (CBR) was successfully constructed in this study. The total E. coli biomass and… read more here.
Keywords: solvent system; aqueous organic; ezetimibe; carbonyl reductase ... See more keywords
Addition of Ezetimibe to statins for patients at high cardiovascular risk: Systematic review of patient‐important outcomes
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DOI: 10.1111/jep.12663
Abstract: Ezetimibe is widely used in combination with statins to reduce low-density lipoprotein. We sought to examine the impact of ezetimibe when added to statins on patient-important outcomes. Medline, EMBASE, CINAHL, and CENTRAL were searched through… read more here.
Keywords: risk; addition; addition ezetimibe; ezetimibe ... See more keywords
Letter by Weingärtner et al Regarding Article, "Ezetimibe Lipid-Lowering Trial on Prevention of Atherosclerotic Cardiovascular Disease in 75 or Older (EWTOPIA 75): A Randomized, Controlled Trial".
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circulationaha.119.043726
Abstract: February 11, 2020 e65 Oliver Weingärtner, MD Eric Sijbrands, MD, PhD Dieter Lütjohann, PhD To the Editor: We congratulate Ouchi et al1 for their excellent analysis of the EWTOPIA 75 (Ezetimibe Lipid-Lowering Trial on Prevention… read more here.
Keywords: cholesterol; cholesterol absorption; lipid lowering; trial ... See more keywords
Pharmacokinetic and pharmacodynamic interaction between ezetimibe and rosuvastatin in healthy male subjects
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DOI: 10.2147/dddt.s146863
Abstract: Background and objective Rosuvastatin and ezetimibe are commonly applied in lipid-lowering pharmacotherapy. However, the pharmacokinetic (PK) interaction was not clear by the coadministration of rosuvastatin and ezetimibe. This study investigated the pharmacodynamic (PD) and PK… read more here.
Keywords: healthy male; rosuvastatin ezetimibe; ezetimibe; male subjects ... See more keywords
Combination Therapy of Ezetimibe and Rosuvastatin for Dyslipidemia: Current Insights
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DOI: 10.2147/dddt.s332352
Abstract: Abstract Cardiovascular disease is one of the leading causes of death around the world with various efforts being made to reduce risk in patients through preventive measures. One major method for prevention has been managing… read more here.
Keywords: combination; therapy; ezetimibe; combination therapy ... See more keywords
Ezetimibe prevents IL-1β-induced inflammatory reaction in mouse chondrocytes via modulating NF-κB and Nrf2/HO-1 signaling crosstalk.
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DOI: 10.2174/1389201023666220104141521
Abstract: BACKGROUND Osteoarthritis, a type of age-related, chronic, degenerative joint disease. Ezetimibe, a cholesterol absorption inhibitor, is widely used for the treatment of various diseases. The role of ezetimibe in osteoarthritis remains unclear. OBJECTIVE This study… read more here.
Keywords: extracellular matrix; ezetimibe; inflammatory reaction; mouse chondrocytes ... See more keywords
Low-density lipoprotein-cholesterol lowering effect of a nutraceutical regimen with or without ezetimibe in hypercholesterolaemic patients with statin intolerance
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DOI: 10.3389/fcvm.2022.1060252
Abstract: Background Statins are the most widely prescribed medication to lower low-density lipoprotein cholesterol (LDL-c). However, a significant portion of patients are unable to tolerate them due to side effects, most commonly muscle related. Nutraceuticals, natural… read more here.
Keywords: density lipoprotein; nutraceutical regimen; combination; ezetimibe ... See more keywords
Treatment with PCSK9 Inhibitor Evolocumab Improves Vascular Oxidative Stress and Arterial Stiffness in Hypercholesterolemic Patients with High Cardiovascular Risk
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DOI: 10.3390/antiox12030578
Abstract: Atherosclerosis and atherosclerotic-related cardiovascular diseases (ASCVD) are characterized by high serum levels of low-density lipoprotein cholesterol (LDL-C) that can promote the generation of reactive oxygen species (ROS). To answer the need for better LDL-C control… read more here.
Keywords: risk; ezetimibe; value; cohort ... See more keywords
Perfluoroalkyl Substance Serum Concentrations and Cholesterol Absorption-Inhibiting Medication Ezetimibe
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DOI: 10.3390/toxics10120799
Abstract: Background: Per- and polyfluoroalkyl substances (PFAS) are human-made compounds with a widespread presence in human blood and other organs. PFAS have been associated with multiple health effects, including higher serum cholesterol and LDL cholesterol. Objective:… read more here.
Keywords: medication; absorption; serum; ezetimibe ... See more keywords