EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00889-0
Abstract: Both EZH2 and its homolog EZH1 function as histone H3 Lysine 27 (H3K27) methyltransferases and repress the transcription of target genes. Dysregulation of H3K27 trimethylation (H3K27me3) plays an important role in the development and progression… read more here.
Keywords: hepatocellular carcinoma; h3k27me3 levels; ezh1; sorafenib ... See more keywords
Abstract 2671: Imipridones ONC201 and ONC206 reduce expression of neogenin and EZH1/2 which correlate with synergy following their combination with EZH1/2 or HDAC inhibitors in treatment of DMG and other tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2671
Abstract: Imipridones are a family of small molecule compounds including ONC201, ONC206 and ONC212 with anti-cancer activity mediated in part through activation of the integrated stress response, induction of TRAIL and its receptor, DR5, and activation… read more here.
Keywords: onc201 onc206; dmg; combination; hdac inhibitors ... See more keywords
Abstract 6267: A novel and potent EZH1/2 dual inhibitor, HM97662 demonstrates antitumor activity in T-cell lymphoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6267
Abstract: Chromatin remodeling is a crucial process for transcriptional regulation, of which dysregulation is often observed in various human cancers. The enhancer of zeste homology 2 (EZH2) and its homolog EZH1 are catalytic subunits of polycomb… read more here.
Keywords: cell; cell lymphoma; hm97662; ezh1 ... See more keywords
Ezh1 Inhibits Commitment to Hemogenic Fate and HSPC Formation during Vertebrate Development
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DOI: 10.1182/blood-2019-131464
Abstract: Understanding how hematopoietic stem cells (HSCs) are specified from mesodermal precursors is essential to the goal of generating patient-specific HSCs capable of multi-potent long-term function. HSCs are born from hemogenic endothelium in select arterial niches… read more here.
Keywords: ezh1; notch; hspc; commitment ... See more keywords
MicroRNA-20a Suppresses Tumor Proliferation and Metastasis in Hepatocellular Carcinoma by Directly Targeting EZH1
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.737986
Abstract: Purpose Hepatocellular carcinoma (HCC), a worldwide leading cause of morbidity and mortality, is the most frequent primary liver tumor. Most HCC patients are diagnosed with advanced liver cancer, resulting in a very low 5-year survival… read more here.
Keywords: proliferation metastasis; hcc; proliferation; effect ... See more keywords
Valemetostat: First approval as a dual inhibitor of EZH1/2 to treat adult T-cell leukemia/lymphoma.
Sign Up to like & getrecommendations! Published in 2022 at "Drug discoveries & therapeutics"
DOI: 10.5582/ddt.2022.01085
Abstract: Adult T-cell leukemia/lymphoma (ATL) is a mature T-cell lymphoma with a poor prognosis. Accumulating trimethylation of histone H3 lysine 27 (H3K27me3) caused by upregulated function of either enhancer of zeste homologue 2 (EZH2) or its… read more here.
Keywords: cell; leukemia lymphoma; adult cell; ezh1 ... See more keywords