CRABP2 accelerates epithelial mesenchymal transition in serous ovarian cancer cells by promoting TRIM16 methylation via upregulating EZH2 expression.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental toxicology"
DOI: 10.1002/tox.23542
Abstract: Recently, it was covered that cellular retinoic acid-binding protein 2 (CRABP2) is upregulated in ovarian cancer and participates in tumor progression, however, the specific mechanism remains to be explored. The pcDNA-CRABP2 or si-CRABP2 was transfected… read more here.
Keywords: expression; ezh2 expression; crabp2; ovarian cancer ... See more keywords
Robust expression of EZH2 in endocervical neoplastic lesions
Sign Up to like & getrecommendations! Published in 2019 at "Virchows Archiv"
DOI: 10.1007/s00428-019-02550-8
Abstract: The aim of this study was to evaluate the nuclear expression of histone methyltransferase enhancer of zeste homolog 2 (EZH2) in endocervical neoplastic lesions such as invasive endocervical adenocarcinoma (ECA) and cervical in situ adenocarcinoma… read more here.
Keywords: robust ezh2; expression; neoplastic lesions; non neoplastic ... See more keywords
EZH2 deficiency attenuates Treg differentiation in rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2020.102404
Abstract: The chromatin modifier enhancer of zeste homolog 2 (EZH2) methylates lysine 27 of histone H3 (H3K27) and regulates T cell differentiation. However, the potential role of EZH2 in the pathogenesis of rheumatoid arthritis (RA) remains… read more here.
Keywords: cd4 cells; differentiation; rheumatoid arthritis; cd4 ... See more keywords
Expression of enhancer of zeste homolog 2 (EZH2) protein in histiocytic and dendritic cell neoplasms with evidence for p-ERK1/2-related, but not MYC- or p-STAT3-related cell signaling
Sign Up to like & getrecommendations! Published in 2018 at "Modern Pathology"
DOI: 10.1038/modpathol.2017.174
Abstract: EZH2 is an important enzymatic subunit of the epigenetic regulator polycomb repressive complex 2 (PRC2), which controls gene silencing through post-translational modification, and is overexpressed in various carcinomas and hematopoietic neoplasms. We found that the… read more here.
Keywords: sarcoma; myc stat3; expression; cell ... See more keywords
The significance of enhancer of zeste homolog 2 (EZH2) expression in spindle cell lesions of the breast
Sign Up to like & getrecommendations! Published in 2021 at "Pathology International"
DOI: 10.1111/pin.13093
Abstract: Spindle cell lesions of the breast are rare entities and pose a diagnostic challenge for pathologists due to overlapping morphologic and immunohistochemical features. We evaluated EZH2 expression in various benign (fibromatosis (n = 8), myofibroblastoma (n = 7), neurofibroma… read more here.
Keywords: cell lesions; spindle cell; expression; ezh2 expression ... See more keywords
326 Clinical outcomes associated with EZH2 expression in high-grade ovarian serous carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2019-igcs.326
Abstract: Objectives Enhancer of Zeste homologue 2 (EZH2), a primary methyltransferase, is over-expressed in cisplatin-resistant ovarian cancer cell lines. We used immunohistochemistry to study the association between EZH2 expression and clinical outcomes in women with high-grade… read more here.
Keywords: expression; high grade; response; carcinoma ... See more keywords
circSYPL1 Promotes the Proliferation and Metastasis of Hepatocellular Carcinoma via the Upregulation of EZH2 Expression by Competing with hsa-miR-506-3p
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/2659563
Abstract: Objective Circular RNAs (circRNAs) and microRNAs are crucial for progressing of hepatocellular carcinoma (HCC). Nonetheless, the function or mechanisms of a newly discovered circRNA, circSYPL1, as well as miR-506-3p, in the progression of HCC are… read more here.
Keywords: mir 506; ezh2 expression; hcc; circsypl1 ... See more keywords
AGE-Induced Suppression of EZH2 Mediates Injury of Podocytes by Reducing H3K27me3
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Nephrology"
DOI: 10.1159/000510140
Abstract: Background: Chronic hyperglycemia, a pivotal feature of diabetes mellitus (DM), initiates the formation of advanced glycation end products (AGEs) and the dysregulation of epigenetic mechanisms, which may cause injury to renal podocytes, a central feature… read more here.
Keywords: suppression ezh2; ezh2; expression; injury ... See more keywords
H3K27me3 and EZH2 expression in melanoma: relevance for melanoma progression and response to immune checkpoint blockade
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Epigenetics"
DOI: 10.1186/s13148-020-0818-7
Abstract: Background Upregulation of the histone methyltransferase enzyme EZH2 and its histone modification H3K27me3 has been linked to melanoma progression, metastasis, and resistance to immune checkpoint blockade (ICB). In clinical trials, EZH2 inhibitors are currently tested… read more here.
Keywords: melanoma; h3k27me3 ezh2; h3k27me3 expression; expression ... See more keywords
The association and prognostic impact of enhancer of zeste homologue 2 expression and epithelial–mesenchymal transition in resected lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0215103
Abstract: Objectives Epithelial-mesenchymal transition (EMT) and the histone methyltransferase Enhancer of Zeste Homologue 2 (EZH2) are important regulators of lung cancer progression and metastasis. Although recent studies support the correlation between EZH2 expression and EMT, no… read more here.
Keywords: lung adenocarcinoma; ezh2 expression; expression; ezh2 ... See more keywords
Overexpression of RACGAP1 by E2F1 Promotes Neuroendocrine Differentiation of Prostate Cancer by Stabilizing EZH2 Expression.
Sign Up to like & getrecommendations! Published in 2023 at "Aging and disease"
DOI: 10.14336/ad.2023.0202
Abstract: Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer. It is characterized by the loss of androgen receptor (AR) signaling in neuroendocrine transdifferentiation, and finally, resistance to AR-targeted therapy. With the application of… read more here.
Keywords: racgap1; prostate; prostate cancer; ezh2 expression ... See more keywords