EZH2‐mediated repression of Dkk1 promotes hepatic stellate cell activation and hepatic fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13153
Abstract: EZH2, a histone H3 lysine‐27‐specific methyltransferase, is involved in diverse physiological and pathological processes including cell proliferation and differentiation. However, the role of EZH2 in liver fibrosis is largely unknown. In this study, it was… read more here.
Keywords: dkk1; ezh2; mediated repression; ezh2 mediated ... See more keywords
EZH2-Mediated H3K27me3 Targets Transcriptional Circuits of Neuronal Differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.814144
Abstract: The Polycomb Repressive Complex 2 (PRC2) plays important roles in the epigenetic regulation of cellular development and differentiation through H3K27me3-dependent transcriptional repression. Aberrant PRC2 activity has been associated with cancer and neurodevelopmental disorders, particularly with… read more here.
Keywords: mediated h3k27me3; ezh2; neuronal differentiation; h3k27me3 targets ... See more keywords