miR‐4448/Girdin/Akt/AMPK axis inhibits EZH2‐mediated EMT and tumorigenesis in small‐cell lung cancer
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DOI: 10.1002/cam4.70093
Abstract: Small‐cell lung cancer (SCLC) shows high enhancer of zeste homolog 2 (EZH2) expressions. EZH2‐mediated epigenetics promote epithelial‐mesenchymal transition (EMT), enhancing invasive and metastatic potential in malignancies. MicroRNAs (miRNAs), small noncoding RNAs, modulate EMT, determining tumor… read more here.
Keywords: cancer; ezh2 mediated; lung cancer; cell lung ... See more keywords
EZH2‐mediated repression of Dkk1 promotes hepatic stellate cell activation and hepatic fibrosis
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DOI: 10.1111/jcmm.13153
Abstract: EZH2, a histone H3 lysine‐27‐specific methyltransferase, is involved in diverse physiological and pathological processes including cell proliferation and differentiation. However, the role of EZH2 in liver fibrosis is largely unknown. In this study, it was… read more here.
Keywords: dkk1; ezh2; mediated repression; ezh2 mediated ... See more keywords
EZH2-Mediated H3K27me3 Targets Transcriptional Circuits of Neuronal Differentiation
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DOI: 10.3389/fnins.2022.814144
Abstract: The Polycomb Repressive Complex 2 (PRC2) plays important roles in the epigenetic regulation of cellular development and differentiation through H3K27me3-dependent transcriptional repression. Aberrant PRC2 activity has been associated with cancer and neurodevelopmental disorders, particularly with… read more here.
Keywords: mediated h3k27me3; ezh2; neuronal differentiation; h3k27me3 targets ... See more keywords
EZH2-mediated H3K27me3 links microbial inosine loss to depression: a gut-brain epigenetic switch
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DOI: 10.7150/thno.120824
Abstract: Background: Depression, the second most prevalent neurological disorder globally, affects over 300 million people and presents an urgent public health challenge. While gut microbiota dysbiosis is increasingly recognized as a key contributor to depression, the… read more here.
Keywords: depressive behaviors; ezh2 mediated; gut; depression ... See more keywords