ASXL1/EZH2 mutations promote clonal expansion of neoplastic HSC and impair erythropoiesis in PMF
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia"
DOI: 10.1038/s41375-018-0159-0
Abstract: Primary myelofibrosis (PMF) is a hematopoietic stem cell (HSC) disease, characterized by aberrant differentiation of all myeloid lineages and profound disruption of the bone marrow niche. PMF samples carry several mutations, but their cell origin… read more here.
Keywords: hsc; pmf; asxl1 ezh2; ezh2 mutations ... See more keywords
Effect of enhancer of zeste homolog 2 mutations on the prognosis of patients with myelodysplastic syndrome
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DOI: 10.1097/md.0000000000021900
Abstract: Abstract Background: Gene mutations with important prognostic roles have been identified in patients with myelodysplastic syndrome (MDS). Overall, it is not yet fully clear whether enhancer of zeste homolog 2 (EZH2) is affected and contributes… read more here.
Keywords: patients myelodysplastic; zeste homolog; myelodysplastic syndrome; effect ... See more keywords
ctDNA Is Useful to Detect Mutations at Codon 641 of Exon 16 of EZH2, a Biomarker for Relapse in Patients with Diffuse Large B-Cell Lymphoma
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DOI: 10.3390/cancers14194650
Abstract: Simple Summary It is well known that epigenetic modifications and proteins involved in this process are important in the biogenesis of diffuse large B-cell lymphoma. In this sense, we decided to analyze the EZH2 mutations,… read more here.
Keywords: cell; cell lymphoma; large cell; diffuse large ... See more keywords