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   Articles with "ezhip" as a keyword



H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2.

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recommendations! Published in 2020 at "Molecular cell"

DOI: 10.1016/j.molcel.2020.09.028

Abstract: Diffuse midline gliomas and posterior fossa type A ependymomas contain the recurrent histone H3 lysine 27 (H3 K27M) mutation and express the H3 K27M-mimic EZHIP (CXorf67), respectively. H3 K27M and EZHIP are competitive inhibitors of… read more here.

Keywords: ezhip impede; k27m ezhip; prc2; impede h3k27 ... See more keywords

EPEN-38. EZH2 INHIBITORY PROTEIN (EZHIP/Cxorf67) EXPRESSION IS HIGHLY CONCORDANT WITH H3K27me3 LOSS AND IS A PROMISING SURROGATE MARKER FOR POSTERIOR FOSSA TYPE A EPENDYMOMAS

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recommendations! Published in 2020 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaa222.173

Abstract: Abstract BACKGROUND Gene expression and DNA methylation have identified 2 distinct clinicopathological subgroups among the WHO Grade II/III posterior fossa (PF) ependymomas (EPN), of which the PF-A molecular subgroup associates with poor outcome. OBJECTIVE To… read more here.

Keywords: ezh2; h3k27me3; expression; h3k27me3 loss ... See more keywords

EPEN-11. CHARACTERIZING EPIGENETIC MODULATIONS AND EZHIP DOWNSTREAM TARGETS IN PFA EPENDYMOMA

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recommendations! Published in 2024 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noae064.213

Abstract: Abstract BACKGROUND Ependymomas can arise from all compartments of the central nervous system and ten distinct molecular groups have been identified in children and adults. In children, the most aggressive group is posterior fossa group… read more here.

Keywords: pfa; ezhip; downstream targets; pfb zfta ... See more keywords

TMOD-10. Mouse Models of H3.3K27M, G34R, and EZHIP Define Distinct Epigenetic Routes to Gliomagenesis

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recommendations! Published in 2025 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaf201.1884

Abstract: Diffuse midline gliomas (DMGs) and posterior fossa group A (PFA) ependymomas are aggressive pediatric brain tumors. Most DMGs harbor histone H3.3K27M or G34R mutations, or exhibit EZHIP overexpression. With a median survival of just 9–15… read more here.

Keywords: ezhip; 3k27m g34r; g34r ezhip; p2a pdgf ... See more keywords

Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas

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recommendations! Published in 2021 at "Science Translational Medicine"

DOI: 10.1126/scitranslmed.abc0497

Abstract: Description Childhood posterior fossa group A ependymomas demonstrate integrated metabolic and epigenetic pathways that can be disrupted by metformin. Understanding childhood ependymomas Children with posterior fossa group A (PFA) ependymomas have a dismal prognosis. PFAs… read more here.

Keywords: childhood; tca cycle; cycle metabolism; ezhip ... See more keywords