Ezrin deficiency triggers glial fibrillary acidic protein upregulation and a distinct reactive astrocyte phenotype
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DOI: 10.1002/glia.24253
Abstract: Astrocytes are increasingly being recognized as contributors to physiological brain function and behavior. Astrocytes engage in glia‐synaptic interactions through peripheral astrocyte processes, thus modulating synaptic signaling, for example, by handling glutamate removal from the synaptic… read more here.
Keywords: fibrillary acidic; ezrin; protein upregulation; acidic protein ... See more keywords
Loss of ezrin expression reduced the susceptibility to the glomerular injury in mice
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DOI: 10.1038/s41598-018-22846-0
Abstract: Ezrin is highly expressed in glomerular podocytes and is reported to form a multi-protein complex with scaffold protein Na+/H+ exchanger regulatory factor 2 (NHERF2) and podocalyxin, a major sialoprotein. Podocalyxin-knockout mice died within 24 h of… read more here.
Keywords: susceptibility glomerular; ezrin; mice; reduced susceptibility ... See more keywords
Role of phospho–ezrin in differentiating thyroid carcinoma
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DOI: 10.1038/s41598-019-42612-0
Abstract: Comprehensive theory explaining the relationship between estrogen (E2) and ezrin in metastasis of thyroid cancer remains non-elicited. In vitro results revealed that E2 could stimulate the expression and phosphorylation of ezrin in a time and… read more here.
Keywords: phospho ezrin; thyroid carcinoma; ezrin;
Acetylation of ezrin regulates membrane–cytoskeleton interaction underlying CCL18-elicited cell migration
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjz099
Abstract: Abstract Ezrin, a membrane–cytoskeleton linker protein, plays an essential role in cell polarity establishment, cell migration, and division. Recent studies show that ezrin phosphorylation regulates breast cancer metastasis by promoting cancer cell survivor and promotes… read more here.
Keywords: acetylation; cell migration; ezrin; cancer ... See more keywords
Ezrin promotes hepatocellular carcinoma progression by modulating glycolytic reprogramming
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DOI: 10.1111/cas.14562
Abstract: Ezrin, one of the ezrin‐radixin‐moesin (ERM) proteins, is involved in the formation of cell membrane processes and has been implicated in the promotion of cancer proliferation and metastasis. However, the possible role of ezrin in… read more here.
Keywords: hepatocellular carcinoma; hcc; ezrin promotes; ezrin ... See more keywords
Role of Ezrin in Asthma-Related Airway Inflammation and Remodeling
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DOI: 10.1155/2022/6255012
Abstract: Ezrin is an actin binding protein connecting the cell membrane and the cytoskeleton, which is crucial to maintaining cell morphology, intercellular adhesion, and cytoskeleton remodeling. Asthma involves dysfunction of inflammatory cells, cytokines, and airway structural… read more here.
Keywords: asthma related; related airway; role; ezrin ... See more keywords
Abstract 3610: Prenylated PALM2 promotes the migration of esophageal squamous cancer cells through activating ezrin
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3610
Abstract: Proteins containing a CAAX motif at the C-terminus can occur prenylation modification and regulate the localization and activity of a series of key regulatory proteins, including RAS superfamily members, heterotrimeric G proteins, nuclear lamina protein,… read more here.
Keywords: palm2; cancer; ezrin; esophageal squamous ... See more keywords
Ca2+ activated cleavage of ezrin visualised dynamically in living myeloid cells during "cell surface area expansion".
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.236968
Abstract: The intracellular events underlying phagocytosis, a crucial event for innate immunity, are still unresolved. In order to test whether the reservoir of membrane for the formation of the phagocytic pseudopodia is maintained by cortical ezrin,… read more here.
Keywords: expansion; cleavage; ca2 activated; ezrin ... See more keywords