Beneficial effect of polyphenols in COVID‐19 and the ectopic F1FO‐ATP synthase: Is there a link?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30306
Abstract: COVID‐19 has been proposed to be an endothelial disease, as endothelial damage and oxidative stress contribute to its systemic inflammatory and thrombotic events. Polyphenols, natural antioxidant compounds appear as promising agents to prevent and treat… read more here.
Keywords: atp synthase; polyphenols covid; ectopic f1fo; f1fo atp ... See more keywords
Phylogenetic Profiling of Mitochondrial Proteins and Integration Analysis of Bacterial Transcription Units Suggest Evolution of F1Fo ATP Synthase from Multiple Modules
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Evolution"
DOI: 10.1007/s00239-017-9819-3
Abstract: ATP synthase is a complex universal enzyme responsible for ATP synthesis across all kingdoms of life. The F-type ATP synthase has been suggested to have evolved from two functionally independent, catalytic (F1) and membrane bound… read more here.
Keywords: atp synthase; evolution; synthase; transcription units ... See more keywords
Low energy costs of F1Fo ATP synthase reversal in colon carcinoma cells deficient in mitochondrial complex IV
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.02.025
Abstract: Abstract Mitochondrial polarisation is paramount for a variety of cellular functions. Under ischemia, mitochondrial membrane potential (&Dgr;&PSgr;m) and proton gradient (&Dgr;pH) are maintained via a reversal of mitochondrial F1Fo ATP synthase (mATPase), which can rapidly… read more here.
Keywords: atp synthase; energy; matpase; free radical ... See more keywords
Mic10, a Core Subunit of the Mitochondrial Contact Site and Cristae Organizing System, Interacts with the Dimeric F1Fo-ATP Synthase.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.03.006
Abstract: The mitochondrial contact site and cristae organizing system (MICOS) is crucial for maintaining the architecture of the mitochondrial inner membrane. MICOS is enriched at crista junctions that connect the two inner membrane domains: inner boundary… read more here.
Keywords: atp synthase; synthase; cristae; f1fo atp ... See more keywords
Unusual features of the c-ring of F1FO ATP synthases
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55092-z
Abstract: Membrane integral ATP synthases produce adenosine triphosphate, the universal “energy currency” of most organisms. However, important details of proton driven energy conversion are still unknown. We present the first high-resolution structure (2.3 Å) of the in… read more here.
Keywords: unusual features; ring f1fo; f1fo atp; atp synthases ... See more keywords
The F1Fo-ATP synthase α subunit of Candida albicans induces inflammatory responses by controlling amino acid catabolism
Sign Up to like & getrecommendations! Published in 2023 at "Virulence"
DOI: 10.1080/21505594.2023.2190645
Abstract: ABSTRACT Sepsis is a leading cause of fatality in invasive candidiasis. The magnitude of the inflammatory response is a determinant of sepsis outcomes, and inflammatory cytokine imbalances are central to the pathophysiological processes. We previously… read more here.
Keywords: atp synthase; synthase subunit; inflammatory responses; f1fo atp ... See more keywords
A Therapeutic Role for the F1FO-ATP Synthase
Sign Up to like & getrecommendations! Published in 2019 at "SLAS Discovery"
DOI: 10.1177/2472555219860448
Abstract: Recently, the F1FO-ATP synthase, due to its dual role of life enzyme as main adenosine triphosphate (ATP) maker and of death enzyme, as ATP dissipator and putative structural component of the mitochondrial permeability transition pore… read more here.
Keywords: f1fo atp; therapeutic role; atp synthase;
Impact of F1Fo-ATP-synthase dimer assembly factors on mitochondrial function and organismic aging
Sign Up to like & getrecommendations! Published in 2018 at "Microbial Cell"
DOI: 10.15698/mic2018.04.625
Abstract: In aerobic organisms, mitochondrial F1Fo-ATP-synthase is the major site of ATP production. Beside this fundamental role, the protein complex is involved in shaping and maintenance of cristae. Previous electron microscopic studies identified the dissociation of… read more here.
Keywords: f1fo atp; atp synthase; dimer assembly; organismic aging ... See more keywords
ATP binding by an F1Fo ATP synthase ε subunit is pH dependent, suggesting a diversity of ε subunit functional regulation in bacteria
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1059673
Abstract: It is a conjecture that the ε subunit regulates ATP hydrolytic function of the F1Fo ATP synthase in bacteria. This has been proposed by the ε subunit taking an extended conformation, with a terminal helix… read more here.
Keywords: atp synthase; f1fo atp; subunit; atp binding ... See more keywords