Phenylglyoxal inhibition of the mitochondrial F1FO-ATPase activated by Mg2+ or by Ca2+ provides clues on the mitochondrial permeability transition pore.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108258
Abstract: Phenylglyoxal (PGO), known to cause post-translational modifications of Arg residues, was used to highlight the role of arginine residues of the F1FO-ATPase, which may be crucial to yield the mitochondrial permeability transition pore (mPTP). In… read more here.
Keywords: f1fo atpase; atpase; ca2; mitochondrial permeability ... See more keywords
Selective growth inhibition by suppression of F1Fo ATPase in canine malignant melanoma cell lines.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of veterinary pharmacology and therapeutics"
DOI: 10.1111/jvp.12336
Abstract: Canine malignant melanoma (CMM) is a highly aggressive and fatal neoplasm. To identify potential therapeutic compounds and/or targets, 320 compounds were screened for their growth inhibitory activity in a CMM line (CMM-1) using a chemical… read more here.
Keywords: canine malignant; growth; f1fo atpase; cell ... See more keywords
Novel Regioselective Synthesis of 1,3,4,5-Tetrasubstituted Pyrazoles and Biochemical Valuation on F1FO-ATPase and Mitochondrial Permeability Transition Pore Formation
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020498
Abstract: An efficient, eco-compatible, and very cheap method for the construction of fully substituted pyrazoles (Pzs) via eliminative nitrilimine-alkene 1,3-dipolar cycloaddition (ENAC) reaction was developed in excellent yield and high regioselectivity. Enaminones and nitrilimines generated in… read more here.
Keywords: permeability transition; transition pore; f1fo atpase; mitochondrial permeability ... See more keywords