Symposium Summaries
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.24151
Abstract: membrane, but rather undergoes constitutive internalization from the cell surface (1). Indeed, the endocytic kinetics for CFTR are remarkably fast, approaching that of nutrient receptors such as the LDL and transferrin receptors (2-4). Although there… read more here.
Keywords: cftr; recycling pathway; f508 cftr; cell surface ... See more keywords
ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter
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DOI: 10.1177/2472555218763310
Abstract: The most common cystic fibrosis–causing mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) is deletion of phenylalanine at residue 508 (∆F508). The ∆F508 mutation impairs folding of nucleotide binding domain 1 (NBD1) and interfacial… read more here.
Keywords: cftr; cell surface; f508 cftr; domain ... See more keywords
The Ubiquitin Ligase RNF34 Participates in the Peripheral Quality Control of CFTR (RNF34 Role in CFTR PeriQC)
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.840649
Abstract: The peripheral protein quality control (periQC) system eliminates the conformationally defective cystic fibrosis transmembrane conductance regulator (CFTR), including ∆F508-CFTR, from the plasma membrane (PM) and limits the efficacy of pharmacological therapy for cystic fibrosis (CF).… read more here.
Keywords: f508 cftr; cftr periqc; rffl; cftr ... See more keywords
Recovery of ΔF508-CFTR Function by Citrate
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14204283
Abstract: Treatment of cystic fibrosis relies so far on expensive and sophisticated drugs. A logical approach to rescuing the defective ΔF508-CFTR protein has not yet been published. Therefore, virtual docking of ATP and CFTR activators to… read more here.
Keywords: f508 cftr; cftr; recovery f508; citrate ... See more keywords