Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools.
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DOI: 10.1016/j.ejmech.2017.12.030
Abstract: The most common CF mutation, F508del, impairs the processing and gating of CFTR protein. This deletion results in the improper folding of the protein and its degradation before it reaches the plasma membrane of epithelial… read more here.
Keywords: evaluation novel; biological evaluation; novel thiazole; thiazole 809 ... See more keywords