Mispacking of the F87 sidechain drives aggregationâpromoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer
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DOI: 10.1002/pro.5101
Abstract: Aberrant formation and deposition of human transthyretin (TTR) aggregates causes transthyretin amyloidosis. To initialize aggregation, transthyretin tetramers must first dissociate into monomers that partially unfold to promote entry into the aggregation pathway. The native TTR… read more here.
Keywords: ttr; tetramer; f87 sidechain; aggregation ... See more keywords