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Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202100757
Abstract: A series of hexafluoroisopropyl carbamates with indolylalkyl‐ and azaindolylalkyl‐substituents at the carbamate nitrogen was synthesized and evaluated for inhibition of the endocannabinoid degrading enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). The synthesized…
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Keywords:
hexafluoroisopropyl carbamates;
carbamates selective;
magl dual;
selective magl ... See more keywords
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Published in 2018 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24120
Abstract: Toll‐like receptor (TLR)3 is a key component of the innate immune response to viral infection. The present study firstly examined whether sex differences exist in TLR3‐induced inflammatory, endocrine, and sickness responses. The data revealed that…
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Keywords:
faah;
tlr3;
tlr3 induced;
independent sex ... See more keywords
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Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111953
Abstract: Fatty acid amide hydrolase (FAAH) is an important enzyme creditworthy of hydrolyzing endocannabinoids and related-amidated signalling lipids, discovery of which has pioneered novel arena of pharmacological canvasses to unwrap its curative potency in various diseased…
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Keywords:
acid amide;
faah;
fatty acid;
amide hydrolase ... See more keywords
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Published in 2020 at "Trends in plant science"
DOI: 10.1016/j.tplants.2019.11.002
Abstract: Fatty acid amide hydrolase (FAAH) is an enzyme that belongs to the amidase signature (AS) superfamily and is widely distributed in multicellular eukaryotes. FAAH hydrolyzes lipid signaling molecules - namely, N-acylethanolamines (NAEs) - which terminates…
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Keywords:
amide hydrolases;
faah;
acid amide;
communication ... See more keywords
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Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20895-z
Abstract: Enhancing endogenous cannabinoid (eCB) signaling has been considered as a potential strategy for the treatment of stress-related conditions. Fatty acid amide hydrolase (FAAH) represents the primary degradation enzyme of the eCB anandamide (AEA), oleoylethanolamide (OEA)…
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Keywords:
faah;
reversible faah;
faah inhibitor;
stress ... See more keywords
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1
Published in 2022 at "eLife"
DOI: 10.1101/2022.08.09.503403
Abstract: Fatty acid amide hydrolase (FAAH) degrades the endocannabinoid anandamide. A polymorphism in FAAH (FAAH C385A) reduces FAAH expression, increases anandamide levels, and increases the risk of obesity. Nevertheless, some studies have found no association between…
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Keywords:
amide hydrolase;
faah;
acid amide;
mice ... See more keywords