Structural and biochemical characterization of FabK from Thermotoga maritima.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.11.141
Abstract: TM0800 from Thermotoga maritima is one of the hypothetical proteins with unknown function. The crystal structure determined at 2.3 Å resolution reveals a two domain structure: the N-terminal domain forming a barrel and the C-terminal forming… read more here.
Keywords: enzymatic activity; thermotoga; thermotoga maritima; fabk ... See more keywords
Small-molecule inhibition of the C. difficile FAS-II enzyme, FabK, results in selective activity.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00293
Abstract: Clostridioides difficile infection (CDI) is a leading cause of significant morbidity, mortality, and healthcare-related costs in the United States. After standard therapy, recurrence rates remain high and multiple recurrences are not uncommon. Causes include treatments… read more here.
Keywords: narrow spectrum; fabk; inhibition; small molecule ... See more keywords