Facile de Novo Sequencing of Tetrazine‐Cyclized Peptides through UV‐Induced Ring‐Opening and Cleavage from the Solid Phase
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DOI: 10.1002/cbic.202200590
Abstract: While most FDA‐approved peptide drugs are cyclic, the robust cyclization chemistry of peptides and the deconvolution of cyclic peptide sequences by using tandem mass spectrometry render cyclic peptide drug discovery difficult. Here we present the… read more here.
Keywords: sequencing tetrazine; cyclic peptides; novo sequencing; solid phase ... See more keywords