Site‐specific functional roles of the Factor X activation peptide in the intrinsic tenase‐mediated Factor X activation
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DOI: 10.1002/1873-3468.14321
Abstract: The conversion of zymogen Factor X (FX) to an active protease involves the removal of a 52‐residue long activation peptide (AP). Through site‐directed mutagenesis, we investigate the role of the AP and demonstrate that the… read more here.
Keywords: intrinsic tenase; factor activation; factor; site ... See more keywords
Evaluation of the mechanisms of heme-induced tissue factor activation: Contribution of innate immune pathways
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DOI: 10.1177/15353702221106475
Abstract: Hemolytic diseases such as Sickle Cell Disease (SCD) are characterized by a natural propensity for both arterial and venous thrombosis. The ability of heme to induce tissue factor (TF) activation has been shown both in… read more here.
Keywords: heme; factor activation; tissue factor; mechanisms heme ... See more keywords