Unraveling the Reaction Mechanism of Russell's Viper Venom Factor X Activator: A Paradigm for the Reactivity of Zinc Metalloproteinases?
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c01156
Abstract: Snake venom metalloproteinases (SVMPs) are important drug targets against snakebite envenoming, the neglected tropical disease with the highest mortality worldwide. Here, we focus on Russell's viper (Daboia russelii), one of the "big four" snakes of… read more here.
Keywords: venom; russell viper; venom factor; viper venom ... See more keywords
Hepatocyte growth factor activator inhibitor-2 stabilizes Epcam and maintains epithelial organization in the mouse intestine
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DOI: 10.1038/s42003-018-0255-8
Abstract: Mutations in SPINT2 encoding the epithelial serine protease inhibitor hepatocyte growth factor activator inhibitor-2 (HAI-2) are associated with congenital tufting enteropathy. However, the functions of HAI-2 in vivo are poorly understood. Here we used tamoxifen-induced… read more here.
Keywords: inhibitor; intestinal epithelium; factor activator; activator inhibitor ... See more keywords
Understanding Russell’s viper venom factor V activator’s substrate specificity by surface plasmon resonance and in-silico studies
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DOI: 10.1371/journal.pone.0181216
Abstract: Blood coagulation factor V (FV) is activated either by Factor X or thrombin, cleaving at three different sites viz., Site I (Arg709-Ser710), site II (Arg1018-Thr1019), and site III (Arg1545-Ser1546). Russell’s viper venom factor V activator… read more here.
Keywords: viper venom; factor activator; site; russell viper ... See more keywords