Articles with "factor activator" as a keyword



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Unraveling the Reaction Mechanism of Russell's Viper Venom Factor X Activator: A Paradigm for the Reactivity of Zinc Metalloproteinases?

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Published in 2023 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.2c01156

Abstract: Snake venom metalloproteinases (SVMPs) are important drug targets against snakebite envenoming, the neglected tropical disease with the highest mortality worldwide. Here, we focus on Russell's viper (Daboia russelii), one of the "big four" snakes of… read more here.

Keywords: venom; russell viper; venom factor; viper venom ... See more keywords
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Hepatocyte growth factor activator inhibitor-2 stabilizes Epcam and maintains epithelial organization in the mouse intestine

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Published in 2019 at "Communications Biology"

DOI: 10.1038/s42003-018-0255-8

Abstract: Mutations in SPINT2 encoding the epithelial serine protease inhibitor hepatocyte growth factor activator inhibitor-2 (HAI-2) are associated with congenital tufting enteropathy. However, the functions of HAI-2 in vivo are poorly understood. Here we used tamoxifen-induced… read more here.

Keywords: inhibitor; intestinal epithelium; factor activator; activator inhibitor ... See more keywords
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Understanding Russell’s viper venom factor V activator’s substrate specificity by surface plasmon resonance and in-silico studies

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Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0181216

Abstract: Blood coagulation factor V (FV) is activated either by Factor X or thrombin, cleaving at three different sites viz., Site I (Arg709-Ser710), site II (Arg1018-Thr1019), and site III (Arg1545-Ser1546). Russell’s viper venom factor V activator… read more here.

Keywords: viper venom; factor activator; site; russell viper ... See more keywords