Quantifying the contribution of transcription factor activity, mutations and microRNAs to CD274 expression in cancer patients
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DOI: 10.1038/s41598-022-08356-0
Abstract: Immune checkpoint inhibitors targeting the programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) axis have been remarkably successful in inducing tumor remissions in several human cancers, yet a substantial number of… read more here.
Keywords: transcription factor; expression; factor activity; cd274 expression ... See more keywords
Accurate differential analysis of transcription factor activity from gene expression
Sign Up to like & getrecommendations! Published in 2019 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz398
Abstract: MOTIVATION Activity of transcriptional regulators are crucial in elucidating the mechanism of phenotypes. However regulatory activity hypotheses are difficult to experimentally test. Therefore we need accurate and reliable computational methods for regulator activity inference. There… read more here.
Keywords: differential analysis; analysis transcription; factor activity; transcription factor ... See more keywords
Factor V activity in apheresis platelets: Implications for management of FV deficiency
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DOI: 10.1111/trf.16179
Abstract: Allogeneic platelet (PLT) infusion is a strategy to raise Factor V (FV) levels in patients with congenital FV deficiency. However, since FV is labile in vitro, we hypothesized that FV activity could be low in… read more here.
Keywords: apheresis platelets; activity apheresis; factor activity; factor ... See more keywords
Abstract 3141: Epiregulon infers single-cell transcription factor activity to dissect mechanisms of lineage plasticity and drug response
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3141
Abstract: Single-cell multiomic technologies enable holistic reconstruction of cell states and hold the potential to identify drivers of tumor evolution and drug resistance. However, the data sparsity of single-cell assays can preclude accurate estimation of transcription… read more here.
Keywords: factor; cell; factor activity; transcription factor ... See more keywords
FcRn augments induction of tissue factor activity by IgG-containing immune complexes.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2019001133
Abstract: Thromboembolism complicates disorders caused by IgG-containing immune complexes (ICs), but the underlying mechanisms are incompletely understood. Prior evidence indicates that induction of tissue factor (TF) on monocytes, a pivotal step in the initiation, localization and… read more here.
Keywords: factor activity; factor; fcrn; igg containing ... See more keywords
Reduced Activity of von Willebrand Factor after Flow-Diverting Stent Implantation for Intracranial Aneurysms: A Link to Acquired von Willebrand Disease?
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Neuroradiology"
DOI: 10.3174/ajnr.a6343
Abstract: BACKGROUND AND PURPOSE: Vascular devices generating high shear stress can cause type 2A acquired von Willebrand disease, which is characterized by low von Willebrand factor activity accompanied by hemorrhagic complications. The braided mesh structure of… read more here.
Keywords: von willebrand; factor activity; willebrand; willebrand factor ... See more keywords
Patient Stratification of Clear Cell Renal Cell Carcinoma Using the Global Transcription Factor Activity Landscape Derived From RNA-Seq Data
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.526577
Abstract: Clear cell renal cell carcinoma represents the most common type of kidney cancer. Precision medicine approach to ccRCC requires an accurate stratification of patients that can predict prognosis and guide therapeutic decision. Transcription factors are… read more here.
Keywords: transcription factor; stratification; cell; factor activity ... See more keywords
No effect of norepinephrine dose on anti-Xa activity in critically ill patients
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Sign Up to like & getrecommendations! Published in 2020 at "International journal of clinical pharmacology and therapeutics"
DOI: 10.5414/cp203640
Abstract: OBJECTIVE Low-molecular-weight heparins are frequently used to prevent venous thromboembolism. Vasopressor therapy may be associated with inadequate anti-factor Xa activity, thereby increasing the risk of venous thromboembolism. We aimed to assess the association between anti-factor… read more here.
Keywords: activity; norepinephrine dose; factor; dose anti ... See more keywords