Inhibitory Effects of 3‐Deoxysappanchalcone on Factor Xa Activity, Platelet Aggregation, and Experimentally Induced Thrombosis
Sign Up to like & getrecommendations! Published in 2025 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.70101
Abstract: 3‐Deoxysappanchalcone (3‐DSC), extracted from Caesalpinia sappan L., is recognized for its anti‐inflammatory, anti‐influenza, and anti‐allergic effects, but its antithrombotic properties have not been investigated. This study explores whether 3‐DSC exhibits antithrombotic effects and examines the… read more here.
Keywords: aggregation; factor activity; platelet aggregation;
Distribution of anti‐factor Xa activity in patients with nonvalvular atrial fibrillation receiving 15 mg dose of edoxaban
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Arrhythmia"
DOI: 10.1002/joa3.13139
Abstract: The distribution of anti‐factor Xa activity (AXA) in patients with nonvalvular atrial fibrillation (NVAF) taking edoxaban 15 mg has not been fully elucidated. read more here.
Keywords: nonvalvular atrial; anti factor; distribution anti; patients nonvalvular ... See more keywords
Cellular reprogramming in vivo initiated by SOX4 pioneer factor activity
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DOI: 10.1038/s41467-024-45939-z
Abstract: Tissue damage elicits cell fate switching through a process called metaplasia, but how the starting cell fate is silenced and the new cell fate is activated has not been investigated in animals. In cell culture,… read more here.
Keywords: pioneer factor; factor; cell fate; factor activity ... See more keywords
Quantifying the contribution of transcription factor activity, mutations and microRNAs to CD274 expression in cancer patients
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-08356-0
Abstract: Immune checkpoint inhibitors targeting the programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1) axis have been remarkably successful in inducing tumor remissions in several human cancers, yet a substantial number of… read more here.
Keywords: transcription factor; expression; factor activity; cd274 expression ... See more keywords
Accurate differential analysis of transcription factor activity from gene expression
Sign Up to like & getrecommendations! Published in 2019 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz398
Abstract: MOTIVATION Activity of transcriptional regulators are crucial in elucidating the mechanism of phenotypes. However regulatory activity hypotheses are difficult to experimentally test. Therefore we need accurate and reliable computational methods for regulator activity inference. There… read more here.
Keywords: differential analysis; analysis transcription; factor activity; transcription factor ... See more keywords
Factor V activity in apheresis platelets: Implications for management of FV deficiency
Sign Up to like & getrecommendations! Published in 2020 at "Transfusion"
DOI: 10.1111/trf.16179
Abstract: Allogeneic platelet (PLT) infusion is a strategy to raise Factor V (FV) levels in patients with congenital FV deficiency. However, since FV is labile in vitro, we hypothesized that FV activity could be low in… read more here.
Keywords: apheresis platelets; activity apheresis; factor activity; factor ... See more keywords
Abstract 3141: Epiregulon infers single-cell transcription factor activity to dissect mechanisms of lineage plasticity and drug response
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3141
Abstract: Single-cell multiomic technologies enable holistic reconstruction of cell states and hold the potential to identify drivers of tumor evolution and drug resistance. However, the data sparsity of single-cell assays can preclude accurate estimation of transcription… read more here.
Keywords: factor; cell; factor activity; transcription factor ... See more keywords
Assessment of Bleeding Severity and Prevalence of Iron Deficiency Among Hemophilia B Carriers By Factor IX Activity Levels
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DOI: 10.1182/blood-2024-194729
Abstract: Background Hemophilia B, traditionally thought to only impact men due to its X-linked recessive inheritance, also affects a subset of women who exhibit increased bleeding tendencies. These women demonstrate a wide range of factor IX… read more here.
Keywords: factor; factor activity; iron deficiency;
FcRn augments induction of tissue factor activity by IgG-containing immune complexes.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2019001133
Abstract: Thromboembolism complicates disorders caused by IgG-containing immune complexes (ICs), but the underlying mechanisms are incompletely understood. Prior evidence indicates that induction of tissue factor (TF) on monocytes, a pivotal step in the initiation, localization and… read more here.
Keywords: factor activity; factor; fcrn; igg containing ... See more keywords
Reduced Activity of von Willebrand Factor after Flow-Diverting Stent Implantation for Intracranial Aneurysms: A Link to Acquired von Willebrand Disease?
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Neuroradiology"
DOI: 10.3174/ajnr.a6343
Abstract: BACKGROUND AND PURPOSE: Vascular devices generating high shear stress can cause type 2A acquired von Willebrand disease, which is characterized by low von Willebrand factor activity accompanied by hemorrhagic complications. The braided mesh structure of… read more here.
Keywords: von willebrand; factor activity; willebrand; willebrand factor ... See more keywords
Patient Stratification of Clear Cell Renal Cell Carcinoma Using the Global Transcription Factor Activity Landscape Derived From RNA-Seq Data
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.526577
Abstract: Clear cell renal cell carcinoma represents the most common type of kidney cancer. Precision medicine approach to ccRCC requires an accurate stratification of patients that can predict prognosis and guide therapeutic decision. Transcription factors are… read more here.
Keywords: transcription factor; stratification; cell; factor activity ... See more keywords