Identification of the primary determining factor(s) governing the oral absorption of edaravone in rats
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.07.052
Abstract: ABSTRACT This study was performed to determine the primary factor(s) governing the oral absorption of edaravone, a novel anti‐oxidant for the treatment of amyotrophic lateral sclerosis, in rats. While the aqueous solubility of edaravone widely… read more here.
Keywords: absorption; governing oral; absorption edaravone; factor governing ... See more keywords
Internal Friction as a Possible Key Factor Governing the Thermosensitivity of TRP Channels
Sign Up to like & getrecommendations! Published in 2019 at "JETP Letters"
DOI: 10.1134/s0021364019150049
Abstract: Six thermo-activated transient receptor potential (TRP) channels are the molecular basis of the thermosensation for mammals. However, the molecular source of their gating remains unknown. In the Letter, we suggest a physically based model for… read more here.
Keywords: internal friction; factor governing; trp channels; key factor ... See more keywords