Factor XI Inhibition to Uncouple Thrombosis From Hemostasis: JACC Review Topic of the Week.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2021.06.010
Abstract: Hemostasis and thrombosis are believed to be so intricately linked that any strategies that reduce thrombosis will have an inevitable impact on hemostasis. Consequently, bleeding is viewed as an unavoidable side effect of anticoagulant therapy.… read more here.
Keywords: inhibition uncouple; thrombosis hemostasis; hemostasis; factor inhibition ... See more keywords
Factor XI Inhibition for the Prevention of Venous Thromboembolism: An Update on Current Evidence and Future perspectives
Sign Up to like & getrecommendations! Published in 2022 at "Vascular Health and Risk Management"
DOI: 10.2147/vhrm.s331614
Abstract: Abstract During the past decade, emergence of direct oral anticoagulants (DOACs) has drastically improved the prevention of thrombosis. However, several unmet needs prevail in the field of thrombosis prevention, even in the DOACs’ era. The… read more here.
Keywords: factor inhibition; prevention venous; prevention; inhibition prevention ... See more keywords
p53 Loss Mediates Hypersensitivity to ETS Transcription Factor Inhibition Based on PARylation-Mediated Cell Death Induction
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12113205
Abstract: Simple Summary ETS transcription factors are potent oncogenic drivers in several cancer types and represent promising therapeutic targets. However, molecular factors influencing response to ETS factor inhibition are widely unknown so far. Here, we uncover… read more here.
Keywords: inhibition; ets transcription; cell death; p53 ... See more keywords
Novel Insights into Factor D Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137216
Abstract: Complement-mediated diseases or complementopathies, such as Paroxysmal nocturnal hemoglobinuria (PNH), cold agglutinin disease (CAD), and transplant-associated thrombotic microangiopathy (TA-TMA), demand advanced complement diagnostics and therapeutics be adopted in a vast field of medical specialties, such… read more here.
Keywords: factor inhibition; inhibition; insights factor; hematology ... See more keywords