The transcription factor c-Maf is essential for the commitment of IL-17-producing γδ T cells
Sign Up to like & getrecommendations! Published in 2018 at "Nature immunology"
DOI: 10.1038/s41590-018-0274-0
Abstract: Abstractγδ T cells that produce the cytokine IL-17 (Tγδ17 cells) are innate-like mediators of immunity that undergo effector programming in the thymus. While regulators of Tγδ17 specialization restricted to various Vγ subsets are known, a… read more here.
Keywords: producing cells; transcription factor; factor maf; factor ... See more keywords
Differential metabolic requirement governed by transcription factor c-Maf dictates innate γδT17 effector functionality in mice and humans
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm9120
Abstract: Cellular metabolism has been proposed to govern distinct γδ T cell effector functions, but the underlying molecular mechanisms remain unclear. We show that interleukin-17 (IL-17)–producing γδ T (γδT17) and interferon-γ (IFN-γ)–producing γδ T (γδT1) cells… read more here.
Keywords: differential metabolic; t17 effector; maf; transcription factor ... See more keywords