Splicing Factor-Mutant Leukemias Are Sensitive to PRMT Inhibitors.
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DOI: 10.1158/2159-8290.cd-rw2019-129
Abstract: Splicing factor mutations increased protein arginine methyltransferase (PRMT) inhibitor sensitivity. read more here.
Keywords: prmt; splicing factor; mutant leukemias; factor mutant ... See more keywords
Mis-Splicing Derived Neoantigens and Cognate T Cell Receptors in Splicing Factor Mutant Myeloid Neoplasms
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DOI: 10.1182/blood-2024-198639
Abstract: Mutations in RNA splicing factors are the most common class of genetic alterations in MDS and are also prevalent in AML. These mutations cause recurrent splicing changes in a highly sequence-specific manner across patients and… read more here.
Keywords: splicing factor; factor mutant; derived neoantigens; splicing derived ... See more keywords