Finding Noemi: The Transcription Factor Mutations Underlying Trait Differentiation Amongst Citrus.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in plant science"
DOI: 10.1016/j.tplants.2019.03.001
Abstract: A recent study by Butelli et al. (Curr. Biol. 2019;29:158-164) has demonstrated that the linked traits of exceptionally low fruit acidity and the absence of anthocyanins in leaves and flowers and proanthocyanidins in seeds of… read more here.
Keywords: noemi transcription; transcription; factor mutations; transcription factor ... See more keywords
Myelodysplastic Syndrome Splicing Factor Mutations Induce R-Loops.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2018-025
Abstract: Mutations in SRSF2 and U2AF35 trigger replication stress and ATR activation via R-loop formation. read more here.
Keywords: induce loops; mutations induce; splicing factor; factor mutations ... See more keywords
Single-cell genomics reveals the genetic and molecular bases for escape from mutational epistasis in myeloid neoplasms.
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DOI: 10.1182/blood.2020006868
Abstract: Large-scale sequencing studies of hematologic malignancies have revealed notable epistasis among high-frequency mutations. One of the most striking examples of epistasis occurs for mutations in RNA splicing factors. These lesions are amongst the most common… read more here.
Keywords: single cell; myeloid neoplasms; splicing factor; factor mutations ... See more keywords
Replication stress signaling is a therapeutic target in myelodysplastic syndromes with splicing factor mutations.
Sign Up to like & getrecommendations! Published in 2020 at "Haematologica"
DOI: 10.3324/haematol.2020.254193
Abstract: Somatic mutations in genes coding for splicing factors, e.g. SF3B1, U2AF1, SRSF2, and others are found in approximately 50% of patients with Myelodysplastic Syndromes (MDS). These mutations have been predicted to frequently occur early in… read more here.
Keywords: splicing factor; factor mutations; factor; replication stress ... See more keywords