Measurement of plasma and platelet tissue factor pathway inhibitor, factor V and Protein S in people with haemophilia
Sign Up to like & getrecommendations! Published in 2019 at "Haemophilia"
DOI: 10.1111/hae.13860
Abstract: Tissue factor pathway inhibitor (TFPI) is a naturally occurring anticoagulant found in plasma, where it circulates bound to lipoproteins, factor V (FV) or Protein S (PS), and in platelets. Therapeutic agents targeting TFPI are under… read more here.
Keywords: factor pathway; pathway inhibitor; tissue factor; factor protein ... See more keywords
Befovacimab, an anti‐tissue factor pathway inhibitor antibody: Early termination of the multiple‐dose, dose‐escalating Phase 2 study due to thrombosis
Sign Up to like & getrecommendations! Published in 2022 at "Haemophilia"
DOI: 10.1111/hae.14595
Abstract: Befovacimab (formerly BAY 1093884) is a fully human monoclonal antibody able to bind to tissue factor pathway inhibitor (TFPI) and developed as a non‐replacement therapy for individuals with haemophilia A/B, with or without inhibitors. read more here.
Keywords: tissue factor; pathway inhibitor; factor pathway; antibody ... See more keywords
Tissue factor pathway inhibitor 2: A potential diagnostic marker for discriminating benign from malignant ovarian tumors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Obstetrics and Gynaecology Research"
DOI: 10.1111/jog.15345
Abstract: Carbohydrate antigen 125 (CA125), CA19‐9, carcinoembryonic antigen (CEA), human epididymis protein 4 (HE4), and the Risk of Ovarian Malignancy Algorithm (ROMA) are widely used as tumor markers and algorithms for the diagnosis of ovarian cancer… read more here.
Keywords: marker; tissue factor; discriminating benign; factor pathway ... See more keywords
The C‐terminus of tissue factor pathway inhibitor‐α inhibits factor V activation by protecting the Arg1545 cleavage site
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13559
Abstract: Essentials The C‐terminus of tissue factor pathway inhibitor (TFPIα) binds to the B‐domain of factor V (FV). The functional consequences of this interaction were investigated in plasma and model systems. The TFPIα C‐terminus inhibited thrombin… read more here.
Keywords: terminus; factor pathway; pathway inhibitor; tissue factor ... See more keywords
Regulation of coagulation by tissue factor pathway inhibitor: Implications for hemophilia therapy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15697
Abstract: Tissue factor pathway inhibitor (TFPI) is an alternatively spliced anticoagulant protein that primarily dampens the initiation phase of coagulation before thrombin is generated. As such, TFPI’s actions are localized to cells expressing TF and to… read more here.
Keywords: coagulation; tissue factor; factor pathway; inhibitor ... See more keywords
Targeted therapy of non-small cell lung cancer and liver cancer: functional nanocarriers for the delivery of cisplatin and tissue factor pathway inhibitor-2.
Sign Up to like & getrecommendations! Published in 2022 at "Chemotherapy"
DOI: 10.1159/000527536
Abstract: INTRODUCTION To construct folic acid-modified PEGylated paramagnetic nanoparticles (MNP) co-carrying tissue factor pathway inhibitor-2 (TFPI-2) and cisplatin (CDDP), and to study the molecular-targeting and inhibitory effects of the nanocomposite on non-small cell lung cancer (NSCLC)… read more here.
Keywords: liver cancer; tissue factor; factor pathway; cddp ... See more keywords
Tissue factor pathway inhibitor is required for cerebrovascular development in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020006054
Abstract: Tissue factor pathway inhibitor (TFPI) inhibits proteases in the blood coagulation cascade that lead to the production of thrombin, including prothrombinase (FXa/FVa), the catalytic complex that directly generates thrombin. Thus, TFPI and FV are directly… read more here.
Keywords: factor pathway; tissue factor; pathology; development ... See more keywords
Expression analysis of tissue factor pathway inhibitors TFPI-1 and TFPI-2 in Paralichthys olivaceus and antibacterial and anticancer activity of derived peptides
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary Research"
DOI: 10.1186/s13567-021-00908-y
Abstract: Tissue factor pathway inhibitors (TFPI), including TFPI-1 and TFPI-2, are Kunitz-type serine protease inhibitors that mainly inhibit the blood coagulation induced by tissue factors. Previous reports on teleost proved TFPI play important roles in innate… read more here.
Keywords: factor pathway; tissue factor; tissue; expression ... See more keywords