Vitamin K Antagonist Reversal for Urgent Surgery Using 4-Factor Prothrombin Complex Concentrates
Sign Up to like & getrecommendations! Published in 2024 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2024.24758
Abstract: This randomized clinical trial assesses the hemostatic efficacy of an investigational 4-factor prothrombin complex concentrate in adults before undergoing urgent surgery with substantial bleeding risk. read more here.
Keywords: factor prothrombin; prothrombin complex; urgent surgery;
Three-Factor Versus Four-Factor Prothrombin Complex Concentrate for the Emergent Management of Warfarin-Associated Intracranial Hemorrhage
Sign Up to like & getrecommendations! Published in 2017 at "Neurocritical Care"
DOI: 10.1007/s12028-017-0374-y
Abstract: BackgroundFour-factor prothrombin complex concentrates (PCC) produce a more rapid and complete INR correction compared with 3-factor PCC in patients receiving warfarin. It is unknown if this improves clinical outcomes in the setting of intracranial hemorrhage… read more here.
Keywords: mortality; factor pcc; factor; warfarin associated ... See more keywords
Efficacy of 4-Factor Prothrombin Complex Concentrates in Factor Xa Inhibitor-Associated Intracranial Bleeding
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DOI: 10.1007/s12028-020-00968-6
Abstract: Background/Objective Intracranial bleeding (ICB) is a feared complication of systemic anticoagulation. Factor Xa inhibitors (FXaI) are used frequently due to their improved safety profile and predictable kinetics. Andexanet alfa was recently approved for emergent reversal… read more here.
Keywords: efficacy; intracranial bleeding; complex concentrates; prothrombin complex ... See more keywords
COLLABORATIVE PRESCRIBING OF FOUR-FACTOR PROTHROMBIN COMPLEX CONCENTRATE FOR EMERGENT ANTICOAGULATION REVERSAL
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DOI: 10.1016/s0735-1097(19)32742-1
Abstract: Emergent reversal of oral anticoagulation (OAC), including vitamin K antagonist (VKA) and direct-acting oral anticoagulant (DOAC) therapy, continues to be an important aspect of OAC due to the potential for serious bleeding events. Four-factor prothrombin… read more here.
Keywords: reversal; complex concentrate; emergent; factor prothrombin ... See more keywords
Comparison of outcomes in patients with intracranial hemorrhage on factor Xa inhibitors versus vitamin K antagonists treated with 4-factor prothrombin complex concentrate
Sign Up to like & getrecommendations! Published in 2018 at "Baylor University Medical Center Proceedings"
DOI: 10.1080/08998280.2018.1440858
Abstract: ABSTRACT The relative clinical efficacy of 4-factor prothrombin complex concentrate (4F-PCC) in oral anticoagulant–associated intracranial hemorrhage is unknown, especially for factor Xa–inhibiting anticoagulants. We report short-term outcomes of patients with oral anticoagulant–associated intracranial hemorrhage on… read more here.
Keywords: intracranial hemorrhage; hemorrhage; prothrombin complex; factor ... See more keywords
551: SINGLE-INSTITUTION COMPARISON OF 4-FACTOR PROTHROMBIN COMPLEX CONCENTRATE VERSUS FRESH FROZEN PLASMA
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/01.ccm.0000528568.22798.ca
Abstract: www.ccmjournal.org Critical Care Medicine • Volume 46 • Number 1 (Supplement) Learning Objectives: Randomized controlled trials have found four-factor prothrombin complex concentrate (4F-PCC) to be as effective as fresh frozen plasma (FFP) for acute reversal… read more here.
Keywords: medicine; fresh frozen; versus; prothrombin complex ... See more keywords
564: CHARACTERIZING THE USE OF 4-FACTOR PROTHROMBIN COMPLEX CONCENTRATE
Sign Up to like & getrecommendations! Published in 2018 at "Critical Care Medicine"
DOI: 10.1097/01.ccm.0000528580.60916.80
Abstract: www.ccmjournal.org Critical Care Medicine • Volume 46 • Number 1 (Supplement) Learning Objectives: Off-label medication use is common in critically ill patients in the United States. Kcentra® is a 4-factor prothrombin complex concentrate (4PCC) approved… read more here.
Keywords: medicine; use; prothrombin complex; factor prothrombin ... See more keywords
476: EVALUATION OF FOUR-FACTOR PROTHROMBIN COMPLEX CONCENTRATE UTILIZATION AT A 591-BED TEACHING HOSPITAL
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DOI: 10.1097/01.ccm.0000551228.12511.91
Abstract: Learning Objectives: Four Factor Prothrombin Complex Concentrate (4F-PCC) is indicated for urgent reversal of vitamin K antagonist in patients with acute major bleeding or in need of urgent surgery/invasive procedure. Vitamin K is administered concurrently… read more here.
Keywords: administration; pcc; four factor; prothrombin complex ... See more keywords
Four-Factor Prothrombin Complex Concentrate in Left Ventricular Assist Device Implantation: Inverse Propensity Score-Weighted Analysis.
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DOI: 10.1097/mat.0000000000001974
Abstract: We compare the effect of intraoperative administration of four-factor prothrombin complex concentrates (PCCs) versus fresh frozen plasma (FFP) on major bleeding, transfusions, and complications. Out of 138 patients undergoing left ventricle assist device (LVAD) implantation,… read more here.
Keywords: factor prothrombin; assist device; prothrombin complex; four factor ... See more keywords
Four-factor Prothrombin Complex Concentrate During Liver Transplantation: A Retrospective Cohort Study
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DOI: 10.1097/txd.0000000000001637
Abstract: Background. Four-factor prothrombin complex concentrate (PCC) is a plasma product that contains factors II, VII, IX, X, protein C, and protein S. PCC can be used off-label to treat coagulopathy during orthotopic liver transplantation (OLT).… read more here.
Keywords: pcc; factor prothrombin; mortality; four factor ... See more keywords
On‐label compared to off‐label four‐factor prothrombin complex concentrate use: a retrospective, observational study
Sign Up to like & getrecommendations! Published in 2019 at "Transfusion"
DOI: 10.1111/trf.15355
Abstract: Four‐factor prothrombin complex concentrate (4F‐PCC) is US Food and Drug Administration approved for the urgent reversal of coagulation factor deficiency induced by a vitamin K antagonist complicated by acute major bleeding or in situations in… read more here.
Keywords: four factor; prothrombin complex; factor; factor prothrombin ... See more keywords