Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins
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DOI: 10.1371/journal.pone.0268857
Abstract: Factor quinolinone inhibitors (FQIs), a first-in-class set of small molecule inhibitors targeted to the transcription factor LSF (TFCP2), exhibit promising cancer chemotherapeutic properties. FQI1, the initial lead compound identified, unexpectedly induced a concentration-dependent delay in… read more here.
Keywords: factor quinolinone; lsf; protein interactions; quinolinone inhibitors ... See more keywords