Soluble forms of cytokine and growth factor receptors: mechanisms of generation and modes of action in the regulation of local and systemic inflammation
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14305
Abstract: Cytokine and growth factor receptors are usually transmembrane proteins, but they can also exist in soluble forms, either through cleavage and release of their ligand‐binding extracellular domain or through the secretion of a soluble isoform.… read more here.
Keywords: factor receptors; cytokine growth; soluble forms; growth factor ... See more keywords
Effective and Specific Gene Silencing of Epidermal Growth Factor Receptors Mediated by Conjugated Oxaborole and Galactose-Based Polymers
Sign Up to like & getrecommendations! Published in 2017 at "ACS Macro Letters"
DOI: 10.1021/acsmacrolett.7b00388
Abstract: Oxaborole-based polymers are stimuli-responsive materials that can reversibly interact with diols at pH values higher than their pKa. The strong binding of the oxaborole with cis-hydroxyl groups allow rapid cross-linking of the polymer chains. In… read more here.
Keywords: oxaborole; factor receptors; growth factor; epidermal growth ... See more keywords
Deciphering the molecular mechanisms of selective non-covalency demonstrated differentially by 9-Allylnaphtho[1,8-ef]isoindole-7,8,10(9H)-trione (C11) against fibroblast growth factor receptors 1–4
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2032355
Abstract: Abstract The specific inhibition of aberrant Fibroblast Growth Factor Receptors (FGFRs) has been identified as a feasible strategy to therapeutically ameliorate their respective carcinogenic involvements. High homology among these proteins has however limited efforts towards… read more here.
Keywords: factor receptors; non covalency; selective non; growth factor ... See more keywords
Targeting coagulation factor receptors – protease‐activated receptors in idiopathic pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13623
Abstract: Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease with a 5‐year mortality rate of > 50% and unknown etiology. Treatment options remain limited and, currently, only two drugs are available, i.e. nintedanib and pirfenidone.… read more here.
Keywords: coagulation; factor receptors; idiopathic pulmonary; coagulation factor ... See more keywords
Abstract 3173: Integrative structural models of oncogenic mutants within the trans- and juxta-membrane region of human epidermal growth factor receptors (HERs)
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3173
Abstract: The trans- and juxtamembrane domains (TMD/JMD) of human epidermal growth factor receptors (HER/EGFR/ErbB) regulate the helix-helix dimerization interface to control receptor tyrosine kinase (RTK) activation. Patient-identified non-small cell lung cancer (NSCLC) mutations occur all along… read more here.
Keywords: factor receptors; epidermal growth; tmd jmd; growth factor ... See more keywords
The level of epidermal growth factor receptors expression is correlated with the advancement of colorectal adenoma: validation of a surface biomarker
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14961
Abstract: Introduction Data about the expression of Epidermal Growth Factor Receptors (EGFRs) in colorectal adenomas remain scarce. Results 101 patients were enrolled including 53 controls. All adenomas (n = 38) and CRC (n = 5) were… read more here.
Keywords: factor receptors; growth factor; expression; surface biomarker ... See more keywords
ERBB2 and ERBB3 Growth Factor Receptors, Neuregulin-1, CD44 and Ki-67 Proliferation Index in Neurofibromatosis Type 1-associated Peripheral Nerve Sheath Tumors
Sign Up to like & getrecommendations! Published in 2022 at "AntiCancer Research"
DOI: 10.21873/anticanres.15712
Abstract: Aim: To characterize the growth pattern and antigen profile of peripheral nerve sheaths tumors (PNST) in a large series of tumors obtained from patients with neurofibromatosis type 1 (NF1). Materials and Methods: Tissue micro-array technique… read more here.
Keywords: factor receptors; growth; proliferation index; pnst ... See more keywords