Enhanced affinity of racemic phosphorothioate DNA with transcription factor SATB1 arising from diastereomer-specific hydrogen bonds and hydrophobic contacts
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DOI: 10.1093/nar/gkaa170
Abstract: Abstract Phosphorothioate modification is commonly introduced into therapeutic oligonucleotides, typically as a racemic mixture in which either of the two non-bridging phosphate oxygens is replaced by sulfur, which frequently increases affinities with proteins. Here, we… read more here.
Keywords: factor satb1; dna; transcription factor; enhanced affinity ... See more keywords