The intraoperative use of recombinant activated factor VII in arterial switch operations.
Sign Up to like & getrecommendations! Published in 2020 at "Cardiology in the young"
DOI: 10.1017/s1047951120004072
Abstract: BACKGROUND The rate of bleeding complications following arterial switch operation is too low to independently justify a prospective randomised study for benefit from recombinant factor VIIa. We aimed to evaluate factor VIIa in a pilot… read more here.
Keywords: study; arterial switch; factor; factor viia ... See more keywords
Local pulmonary administration of factor VIIa (rFVIIa) in massive pulmonary haemorrhage in post-operative cardiac infant.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiology in the young"
DOI: 10.1017/s1047951122003006
Abstract: Diffuse pulmonary haemorrhage is an ominous condition that has a high paediatric mortality rate. Recombinant activated factor VIIa (rFVIIa) is a powerful haemostatic agent which has been used intravenously in life-threatening haemorrhage in variety of… read more here.
Keywords: factor viia; massive pulmonary; rfviia massive; haemorrhage ... See more keywords
Separate Effect of Perioperative Recombinant Human Factor VIIa Administration and Packed Red Blood Cell Transfusions on Midterm Survival in Lung Transplantation Recipients.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cardiothoracic and vascular anesthesia"
DOI: 10.1053/j.jvca.2020.05.038
Abstract: OBJECTIVE The purpose of this study was to determine the relationship between blood product transfusion, with or without recombinant human activated factor VIIa, and survival after lung transplantation. DESIGN Retrospective analysis of a single center… read more here.
Keywords: factor viia; recombinant human; red blood; packed red ... See more keywords
Engineering of a membrane-triggered activity switch in coagulation factor VIIa
Sign Up to like & getrecommendations! Published in 2017 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1618713114
Abstract: Significance Coagulation factor VIIa (FVIIa) is an intrinsically poor serine protease that requires assistance from its cofactor tissue factor (TF) to trigger the extrinsic pathway of blood coagulation. TF stimulates FVIIa through allosteric maturation of… read more here.
Keywords: factor viia; fviia; coagulation; membrane ... See more keywords
Contribution of allosteric disulfide in the structural regulation of membrane-bound tissue factor–factor VIIa binary complex
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1526118
Abstract: Abstract Two distinct populations, active and cryptic forms of tissue factor (TF), reside on the cell surface. Apart from phospholipid contribution, various models have been introduced to explain decryption/encryption of TF. The proposed model, the… read more here.
Keywords: factor viia; disulfide bond; membrane bound; bond ... See more keywords
Activated factor XI is associated with increased factor VIIa – Antithrombin complexes in stable coronary artery disease: Impact on cardiovascular outcomes
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Clinical Investigation"
DOI: 10.1111/eci.13857
Abstract: Coronary artery disease (CAD) is associated with a prothrombotic tendency including increased factor (F) VIIa‐antithrombin (FVIIa‐AT) complexes, a measure of tissue factor (TF) exposure, and activated FXI (FXIa). We investigated whether increased FVIIa–AT complexes are… read more here.
Keywords: increased factor; factor viia; viia antithrombin; artery disease ... See more keywords
Plasma‐derived factor VIIa and factor X mixture agent (MC710) prophylaxis in haemophilia B patients with inhibitors
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DOI: 10.1111/hae.14710
Abstract: Haemophilia B patients with factor IX inhibitors have particularly unmet needs for conventional therapy. read more here.
Keywords: haemophilia patients; factor viia; factor; derived factor ... See more keywords
Evolutionary conservation of the allosteric activation of factor VIIa by tissue factor in lamprey: comment
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.14142
Abstract: We read with great interest the article on allostery in a protease from the blood coagulation cascade by Beeler et al.(1) in a recent issue of Journal of Thrombosis and Haemostasis. Herein, the authors conclude that… read more here.
Keywords: factor viia; coagulation; factor lamprey; tissue factor ... See more keywords
Recombinant Factor VIIa–Mediated Activation of Prothrombin Complex Concentrates
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DOI: 10.1177/1076029616663848
Abstract: Recombinant factor VIIa (rFVIIa) is used in the management of bleeding in patients with hemophilia. A generic biosimilar version of NovoSeven is also developed (AryoSeven). To compare the activation profile of NovoSeven and AryoSeven, 2… read more here.
Keywords: factor viia; recombinant factor; prothrombin; activation ... See more keywords
Eptacog beta, a novel recombinant factor VIIa, for the treatment of hemophilia.
Sign Up to like & getrecommendations! Published in 2022 at "Drugs of today"
DOI: 10.1358/dot.2022.58.3.3381593
Abstract: Hemophilia A and B are X-linked hereditary bleeding disorders due to factor VIII (FVIII) or factor IX (FIX) deficiency, respectively. Major advancements have been made in the care of patients with hemophilia, yet the development… read more here.
Keywords: factor viia; recombinant factor; eptacog beta; hemophilia ... See more keywords