Multicenter performance evaluation and reference range determination of a new one‐stage factor VIII assay
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24294
Abstract: We conducted a multicenter evaluation of a new one‐stage factor VIII (FVIII) assay (Roche Diagnostics), intended for the quantitative assessment of FVIII activity. We evaluated the analytical performance of the FVIII assay on the cobas… read more here.
Keywords: evaluation; one stage; multicenter; factor viii ... See more keywords
Chromogenic Factor VIII Assays for Improved Diagnosis of Hemophilia A.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7196-1_21
Abstract: Hemophilia A is an inherited bleeding disorder caused by a reduced level of factor VIII coagulant activity (FVIII:C) in blood. Bleeding episodes may occur spontaneously in the severe form of hemophilia or after trauma in… read more here.
Keywords: hemophilia; factor viii; chromogenic factor; diagnosis ... See more keywords
Quantification of Coagulation Factor VIII by Selective Reaction Monitoring.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7312-5_22
Abstract: Coagulation factor VIII (FVIII) is an important glycoprotein involved in the extrinsic coagulation cascade. Mutations in FVIII gene results in hemophilia A, a recessive coagulation disorder that is clinically managed by administration of purified FVIII… read more here.
Keywords: coagulation; reaction monitoring; factor viii; coagulation factor ... See more keywords
Subcutaneous administration of Lyso‐phosphatidylserine nanoparticles induces immunological tolerance towards Factor VIII in a Hemophilia A mouse model
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.07.018
Abstract: ABSTRACT A major complication with enzyme replacement therapy of Factor VIII (FVIII) in Hemophilia A (HA) is the development of anti‐drug antibodies. Recently, we have shown that FVIII administration in the presence of heterogeneous phosphatidylserine… read more here.
Keywords: administration; tolerance towards; administration lyso; tolerance ... See more keywords
Factor VIII/protein C ratio independently predicts liver-related events but does not indicate a hypercoagulable state in ACLD.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2021.12.038
Abstract: BACKGROUND&AIMS It has been suggested that the ratio of procoagulant factor VIII to anticoagulant protein C (FVIII/PC) reflects the haemostatic equilibrium. Moreover, FVIII/PC predicted decompensation/death in a small study not accounting for portal hypertension severity.… read more here.
Keywords: hypercoagulable state; liver disease; fviii; factor viii ... See more keywords
Choice of factor VIII/IX regimen in adolescents and young adults with severe or moderately severe haemophilia. A French national observational study (ORTHem 15-25).
Sign Up to like & getrecommendations! Published in 2017 at "Thrombosis research"
DOI: 10.1016/j.thromres.2016.12.023
Abstract: INTRODUCTION The value and challenges of long-term prophylaxis (LTP) in adolescents and young adults need further characterisation. AIM To determine the proportions of adolescents and young adults with severe or moderately severe haemophilia in France… read more here.
Keywords: adolescents young; treatment; young adults; factor viii ... See more keywords
Effects of Product Handling Parameters on Particle Levels in a Commercial Factor VIII Product: Impacts and Mitigation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.08.022
Abstract: To reduce the risk of immunogenicity that may be caused by therapeutic protein products, it is important to properly characterize subvisible particles and to develop strategies to reduce the levels of particles delivered to patients.… read more here.
Keywords: particle levels; viii product; product; factor viii ... See more keywords
Polysialic acid-mediated activity measurement of polysialylated recombinant coagulation factor VIII.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2019.10.019
Abstract: Measurement of modified biologic including coagulation factors with extended half-life obtained for example by polysialylation pose an analytical challenge especially if both biological activity and presence of modification have to be determined. Analytical methods applied… read more here.
Keywords: polysialic acid; acid mediated; factor viii; polysialylated recombinant ... See more keywords
Effect of the First Factor VIII Infusions on Immunological Biomarkers in Previously Untreated Patients with Hemophilia A from the HEMFIL Study.
Sign Up to like & getrecommendations! Published in 2021 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0040-1722353
Abstract: Hemophilia A (HA) is an inherited bleeding disorder which requires continuous replacement with factor (F) VIII concentrate. The main complication of HA is the development of neutralizing alloantibodies which inhibit FVIII activity (inhibitors). The objective… read more here.
Keywords: effect first; factor viii; infusions immunological; biomarkers previously ... See more keywords
A Closed-Tube Nested Quantitative PCR Assay for Rapid Detection of Intron 22 Inversions in the Factor VIII Gene.
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DOI: 10.1093/clinchem/hvz021
Abstract: BACKGROUND An inversion of intron 22 in the Factor VIII gene (Inv22) is the causative mutation for 45% of severe hemophilia A cases. Available methods for molecular diagnosis of Inv22 are generally tedious and not… read more here.
Keywords: closed tube; tube nested; nested quantitative; factor viii ... See more keywords
Twice Weekly Vs. Thrice Weekly Low-Dose Prophylactic Factor VIII Therapy in Children with Hemophilia A: An Open Label Randomized Trial.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of tropical pediatrics"
DOI: 10.1093/tropej/fmac039
Abstract: INTRODUCTION Low dose factor VIII prophylactic therapy in hemophilia has not been well established till date. This randomized controlled trial compared the efficacy of twice vs. thrice weekly schedule of low dose prophylactic factor VIII… read more here.
Keywords: twice weekly; factor; group; thrice weekly ... See more keywords