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2
Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c02130
Abstract: Factor XIa (FXIa) in the intrinsic pathway of the coagulation process has been proven to be an effective and safe target for anticoagulant discovery with limited or no bleeding. Numerous small-molecule FXIa inhibitors (SMFIs) with…
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Keywords:
xia inhibitors;
anticoagulation therapy;
factor xia;
discovery ... See more keywords
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1
Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00173
Abstract: With the introduction of thrombin and factor Xa inhibitors to the oral anticoagulant market, significant improvements in both efficacy and safety have been achieved. Early clinical and preclinical data suggest that inhibitors of factor XIa…
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Keywords:
factor xia;
chemistry;
new anticoagulants;
inhibitors new ... See more keywords
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0
Published in 2021 at "Scientific reports"
DOI: 10.1038/s41598-021-84618-7
Abstract: Coagulation Factor XIa (FXIa) is an emerging target for antithrombotic agent development. The M358R variant of the serpin alpha-1 antitrypsin (AAT) inhibits both FXIa and other proteases. Our aim was to enhance the specificity of…
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Keywords:
m358r;
factor xia;
phage;
aat ... See more keywords
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1
Published in 2023 at "Molecules"
DOI: 10.3390/molecules28093851
Abstract: Despite extensive research in the field of thrombotic diseases, the prevention of blood clots remains an important area of study. Therefore, the development of new anticoagulant drugs with better therapeutic profiles and fewer side effects…
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Keywords:
evaluation;
new hybrid;
synthesis;
inhibitors factor ... See more keywords