Factor XII deficiency is common in domestic cats and associated with two high frequency F12 mutations.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.04.053
Abstract: Factor XII (FXII) is a coagulation protein that initiates surface-activation of the coagulation cascade in vitro. The protein's in vivo role, however, remains poorly defined. Factor XII deficiency, or Hageman trait, is a rare hereditary… read more here.
Keywords: factor xii; domestic cats; f12; xii deficiency ... See more keywords
Repeated attacks of type III hereditary angioedema with factor XII mutation during pregnancy.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of obstetric anesthesia"
DOI: 10.1016/j.ijoa.2018.07.003
Abstract: In type III hereditary angioedema (HAE type III), the phenotype is the same as type I and type II disease, but the level and function of C1-esterase inhibitor (C1-INH) is normal. Hereditary angioedema type III… read more here.
Keywords: pregnancy; factor xii; hereditary angioedema; type ... See more keywords
A Short Isoform of Coagulation Factor XII mRNA Is Expressed by Neurons in the Human Brain
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.05.040
Abstract: Coagulation factor XII (FXII) is synthesized in the liver and secreted into the circulation, where it initiates the contact activation system. Although typically thought to be restricted to the circulation, FXII protein has been found… read more here.
Keywords: isoform; factor xii; coagulation factor; fxii ... See more keywords
Prophylactic use of an anti-activated factor XII monoclonal antibody, garadacimab, for patients with C1-esterase inhibitor-deficient hereditary angioedema: a randomised, double-blind, placebo-controlled, phase 2 trial
Sign Up to like & getrecommendations! Published in 2022 at "The Lancet"
DOI: 10.1016/s0140-6736(21)02225-x
Abstract: BACKGROUND Hereditary angioedema is associated with dysregulation of the kallikrein-kinin system. Factor XII (FXII) is a key initiator of the kallikrein-kinin system, which produces bradykinin, a central mediator of angioedema. Garadacimab (CSL Behring) is a… read more here.
Keywords: placebo; treatment; factor xii; hereditary angioedema ... See more keywords
A single-domain antibody targeting factor XII inhibits both thrombosis and inflammation
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-51745-4
Abstract: Factor XII (FXII) is the zymogen of the plasma protease FXIIa that activates the intrinsic coagulation pathway and the kallikrein kinin-system. The role of FXII in inflammation has been obscure. Here, we report a single-domain… read more here.
Keywords: antibody; single domain; factor xii; inflammation ... See more keywords
Coagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-62789-5
Abstract: Coagulation factor XII has been identified as a potential drug target that could prevent thrombosis without increasing the risk of bleeding. However, human data to support the development of factor XII-directed therapeutics are lacking. To… read more here.
Keywords: factor; factor xii; venous thromboembolism; coagulation factor ... See more keywords
Antithrombotic coating with sheltered positive charges prevents contact activation by controlling factor XII–biointerface binding
Sign Up to like & getrecommendations! Published in 2024 at "Nature Materials"
DOI: 10.1038/s41563-024-02046-0
Abstract: Antithrombotic surfaces that prevent coagulation activation without interfering with haemostasis are required for blood-contacting devices. Such materials would restrain device-induced thrombogenesis and decrease the need for anticoagulant use, thereby reducing unwanted bleeding. Here, by optimizing… read more here.
Keywords: sheltered positive; coating sheltered; activation; factor xii ... See more keywords
The potential of factor XII inhibitors in preventing hereditary angioedema attacks
Sign Up to like & getrecommendations! Published in 2025 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2025.2512128
Abstract: ABSTRACT Introduction Hereditary angioedema (HAE) is a rare genetic disorder characterized by recurrent episodes of subcutaneous and/or submucosal swelling (angioedema). Current HAE-specific medications primarily focus on either inhibiting plasma bradykinin or kallikrein, or replacing C1-esterase… read more here.
Keywords: factor xii; hereditary angioedema; fxii inhibition; potential factor ... See more keywords
Introduction to current issue.
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DOI: 10.1097/moh.0000000000000370
Abstract: DOI:10.1097/MOH.0000000000000370 As an introduction to my inaugural issue as associate editor for hemostasis and thrombosis of Current Opinion in Hematology, I want to present the themes that comprise this year’s edition. The field of hemostasis… read more here.
Keywords: issue; hematology; factor xii; factor xiia ... See more keywords
Revisiting the Link Between Factor XII and Recurrent Pregnancy Loss: A Scoping Review
Sign Up to like & getrecommendations! Published in 2025 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.70127
Abstract: Pregnancy loss affects approximately 23% of women, with 1%–3% experiencing recurrent pregnancy loss (RPL), defined as two or more consecutive miscarriages. Despite extensive research, up to 50% of RPL cases remain unexplained, making it a… read more here.
Keywords: pregnancy loss; recurrent pregnancy; factor xii; pregnancy ... See more keywords
What the Neighbors Say
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.14583
Abstract: Zamolodchikov et al. A short isoform of coagulation factor XII mRNA is expressed by neurons in the human brain. Neuroscience 2019; 413:294‐307. Factor XII is reported in brains of Alzheimer's disease and multiple sclerosis patients,… read more here.
Keywords: factor xii; hgf; splice variant; factor ... See more keywords