Factor XII deficiency is common in domestic cats and associated with two high frequency F12 mutations.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.04.053
Abstract: Factor XII (FXII) is a coagulation protein that initiates surface-activation of the coagulation cascade in vitro. The protein's in vivo role, however, remains poorly defined. Factor XII deficiency, or Hageman trait, is a rare hereditary… read more here.
Keywords: factor xii; domestic cats; f12; xii deficiency ... See more keywords
Repeated attacks of type III hereditary angioedema with factor XII mutation during pregnancy.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of obstetric anesthesia"
DOI: 10.1016/j.ijoa.2018.07.003
Abstract: In type III hereditary angioedema (HAE type III), the phenotype is the same as type I and type II disease, but the level and function of C1-esterase inhibitor (C1-INH) is normal. Hereditary angioedema type III… read more here.
Keywords: pregnancy; factor xii; hereditary angioedema; type ... See more keywords
A Short Isoform of Coagulation Factor XII mRNA Is Expressed by Neurons in the Human Brain
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.05.040
Abstract: Coagulation factor XII (FXII) is synthesized in the liver and secreted into the circulation, where it initiates the contact activation system. Although typically thought to be restricted to the circulation, FXII protein has been found… read more here.
Keywords: isoform; factor xii; coagulation factor; fxii ... See more keywords
Prophylactic use of an anti-activated factor XII monoclonal antibody, garadacimab, for patients with C1-esterase inhibitor-deficient hereditary angioedema: a randomised, double-blind, placebo-controlled, phase 2 trial
Sign Up to like & getrecommendations! Published in 2022 at "The Lancet"
DOI: 10.1016/s0140-6736(21)02225-x
Abstract: BACKGROUND Hereditary angioedema is associated with dysregulation of the kallikrein-kinin system. Factor XII (FXII) is a key initiator of the kallikrein-kinin system, which produces bradykinin, a central mediator of angioedema. Garadacimab (CSL Behring) is a… read more here.
Keywords: placebo; treatment; factor xii; hereditary angioedema ... See more keywords
Introduction to current issue.
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DOI: 10.1097/moh.0000000000000370
Abstract: DOI:10.1097/MOH.0000000000000370 As an introduction to my inaugural issue as associate editor for hemostasis and thrombosis of Current Opinion in Hematology, I want to present the themes that comprise this year’s edition. The field of hemostasis… read more here.
Keywords: issue; hematology; factor xii; factor xiia ... See more keywords
What the Neighbors Say
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.14583
Abstract: Zamolodchikov et al. A short isoform of coagulation factor XII mRNA is expressed by neurons in the human brain. Neuroscience 2019; 413:294‐307. Factor XII is reported in brains of Alzheimer's disease and multiple sclerosis patients,… read more here.
Keywords: factor xii; hgf; splice variant; factor ... See more keywords
Annexin A4 inhibits sulfatide‐induced activation of coagulation factor XII
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.14789
Abstract: Factor XII (FXII) is a plasma serine protease that initiates the intrinsic pathway of blood coagulation upon contact with anionic substances, such as the sulfated glycolipid sulfatide. Annexins (ANXs) have been implicated in the regulation… read more here.
Keywords: coagulation; factor xii; annexin inhibits; inhibits sulfatide ... See more keywords
CpaA Is a Glycan-Specific Adamalysin-like Protease Secreted by Acinetobacter baumannii That Inactivates Coagulation Factor XII
Sign Up to like & getrecommendations! Published in 2018 at "mBio"
DOI: 10.1128/mbio.01606-18
Abstract: Ventilator-associated pneumonia and catheter-related bacteremia are the most common and severe infections caused by Acinetobacter baumannii. Besides the capsule, lipopolysaccharides, and the outer membrane porin OmpA, little is known about the contribution of secreted proteins… read more here.
Keywords: factor xii; coagulation factor; cpaa; factor ... See more keywords
Factor XII Deficiency in ECMO Patients
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DOI: 10.1182/blood-2019-131614
Abstract: Background: Extracorporeal membrane oxygenation (ECMO) for cardiopulmonary support of critically ill patients is used frequently in the pediatric and adult population. Although a lifesaving modality, it is burdened with high morbidity and mortality as a… read more here.
Keywords: ffp; factor xii; xii deficiency; deficiency ... See more keywords
Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2021005976
Abstract: Key Points The FXII EGF1 domain promotes surface binding, FXII activation on surfaces, and FXIIa activation of prekallikrein on surfaces. The FXII FN2 and KNG domains are part of a mechanism that restricts FXII activation… read more here.
Keywords: surface dependent; dependent factor; xii activation; model surface ... See more keywords
Associations between coagulation factor XII, coagulation factor XI, and stability of venous thromboembolism: A case-control study
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v10.i9.2700
Abstract: BACKGROUND Pulmonary embolism (PE) is a fatal clinical syndrome that is generally caused by an embolus from unstable deep venous thrombosis (DVT). However, clinical and biochemical factors that are related to the stability of DVT… read more here.
Keywords: dvt; factor; coagulation factor; stability ... See more keywords