Engineering the Cyclization Loop of MCoTI-II Generates Targeted Cyclotides that Potently Inhibit Factor XIIa.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01080
Abstract: Factor XIIa (FXIIa) is a promising target for developing new drugs that prevent thrombosis without causing bleeding complications. A native cyclotide (MCoTI-II) is gaining interest for engineering FXIIa-targeted anticoagulants as this peptide inhibits FXIIa but… read more here.
Keywords: loop; mcoti; cyclization loop; factor xiia ... See more keywords
Introduction to current issue.
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Hematology"
DOI: 10.1097/moh.0000000000000370
Abstract: DOI:10.1097/MOH.0000000000000370 As an introduction to my inaugural issue as associate editor for hemostasis and thrombosis of Current Opinion in Hematology, I want to present the themes that comprise this year’s edition. The field of hemostasis… read more here.
Keywords: issue; hematology; factor xii; factor xiia ... See more keywords